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Basmisanil

Name: Basmisanil
Brand: TargetMol
SKU: T7165
Price: 233 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.42%

货号 T7165Cas号 1159600-41-5

别名 巴米沙尼, RO5186582, RG1662

Basmisanil (RG1662) 是高度选择性GABAAα5负调节剂，用于治疗与唐氏综合症相关的认知障碍。

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Basmisanil

一键复制产品信息

很棒

纯度: 99.42%

货号 T7165 别名 巴米沙尼, RO5186582, RG1662Cas号 1159600-41-5

Basmisanil (RG1662) 是高度选择性GABAAα5负调节剂，用于治疗与唐氏综合症相关的认知障碍。

规格	价格	库存
1 mg	¥ 233	现货
5 mg	¥ 536	现货
10 mg	¥ 783	现货
25 mg	¥ 1,290	现货
50 mg	¥ 1,930	现货
100 mg	¥ 2,880	现货
500 mg	¥ 6,570	现货
1 mL x 10 mM (in DMSO)	¥ 582	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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COA HPLC HNMR 产品操作手册

产品介绍

Basmisanil AI Summary

Basmisanil exhibits diverse bioactivities, particularly targeting GABA-A receptors and SARS-CoV-2. It shows a high binding affinity to various GABA-A receptor subunits, notably alpha1, alpha2, alpha3, and alpha5, with Ki values reaching 4.4 nM for the alpha5 subunit. The compound functions as a negative allosteric modulator at the alpha5 and alpha1 subunits, decreasing activity significantly at different concentrations. In antiviral studies, Basmisanil demonstrated moderate inhibitory activity against the SARS-CoV-2 3CL-Pro protease, with a 10.94% inhibition at 20µM concentration, and minimal inhibition of SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10µM after 48 hours of exposure. Additionally, the compound's impact on cell viability varies across different cell lines, promoting growth in HEK293T and U2OS cells while showing mixed effects in human fibroblast cells. Basmisanil also demonstrates moderate metabolic stability in both human and Wistar rat liver microsomes..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Basmisanil (RG1662) is a negative allosteric modulator/inverse agonist of GABAAα5 receptors.Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairments associated with Down syndrome.
别名	巴米沙尼, RO5186582, RG1662

化学信息

分子量	445.46
分子式	C₂₁H₂₀FN₃O₅S
CAS No.	1159600-41-5
Smiles	Cc1onc(c1COc1ccc(cn1)C(=O)N1CCS(=O)(=O)CC1)-c1ccc(F)cc1
密度	1.388 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 32 mg/mL (71.84 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.49 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2449 mL	11.2244 mL	22.4487 mL	112.2435 mL
5 mM	0.4490 mL	2.2449 mL	4.4897 mL	22.4487 mL
10 mM	0.2245 mL	1.1224 mL	2.2449 mL	11.2244 mL
20 mM	0.1122 mL	0.5612 mL	1.1224 mL	5.6122 mL
50 mM	0.0449 mL	0.2245 mL	0.4490 mL	2.2449 mL