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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Naphazoline hydrochloride

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纯度: 97.93%

货号 T0446Cas号 550-99-2

别名 盐酸萘甲唑啉, Rhinantin, Naphazoline HCl, Albalon

Naphazoline hydrochloride (Naphazoline HCl) 是一种咪唑啉衍生物，是一种眼血管收缩剂。

Naphazoline hydrochloride
其他形式的 “Naphazoline hydrochloride”:
Naphazoline hydrochloride (Standard)
Naphazoline nitrate
Naphazoline

Naphazoline hydrochloride

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Rating icon 很棒

纯度: 97.93%

货号 T0446 别名 盐酸萘甲唑啉, Rhinantin, Naphazoline HCl, AlbalonCas号 550-99-2

Naphazoline hydrochloride (Naphazoline HCl) 是一种咪唑啉衍生物，是一种眼血管收缩剂。

规格价格库存数量
500 mg
¥ 99
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产品介绍

Naphazoline hydrochloride AI Summary
Naphazoline hydrochloride exhibits strong adrenergic activity with an EC50 of 12.0 nM against the Alpha-1 adrenergic receptor in rat aorta and an IC50 of 0.0011 nM against the Alpha-2 adrenergic receptor in human platelets. It shows potency ratios of 25.8 for Alpha-1 and 3.0 for Alpha-2 compared to medetomidine, indicating its high specificity and efficacy for these receptors. Additionally, it has antiplasmodial activity against Plasmodium falciparum strains GB4 and W2 with an IC50 of 10000.0 nM after 72 hours. Naphazoline hydrochloride demonstrates various bioactivities, including inhibition of the ERK signaling pathway stimulated by EGF, induction of DNA re-replication in SW480 colon adenocarcinoma cells, and potential effects on hTAAR1 as both an agonist and desensitizer. It shows inhibition of USP1/UAF1 and MBNL1-poly(CUG) RNA binding, suggesting implications in cancer cell proliferation, signaling pathways, and molecular interactions. The compound also inhibits sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells, with inhibition levels of 100.66% and 95.85%, respectively, at 10 uM concentration. However, it shows minimal activity in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2, with an inhibition index of 0.01362, while demonstrating a 5.6% inhibition rate against SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 uM after 48 hours. Moreover, Naphazoline hydrochloride exhibits a 27.49% inhibition on SARS-CoV-2 3CL-Pro protease activity at a concentration of 20µM. It shows some antifungal activity against Candida albicans and Cryptococcus neoformans with inhibitions of 3.38% and -4.12%, respectively. The compound also demonstrates antibacterial activities against various bacteria, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus MRSA with inhibitions of 2.28%, 13.63%, 21.25%, 22.4%, and 21.19%, respectively..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Naphazoline hydrochloride (Naphazoline HCl) is an adrenergic vasoconstrictor agent used as a decongestant.
别名盐酸萘甲唑啉, Rhinantin, Naphazoline HCl, Albalon
化学信息
分子量246.74
分子式C14H15ClN2
CAS No.550-99-2
SmilesCl.C(C1=NCCN1)c1cccc2ccccc12
密度1.15 g/cm3
颜色White
物理性状Solid
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 9 mg/mL (36.48 mM), Sonication is recommended.
Ethanol: 21 mg/mL (85.11 mM), Sonication is recommended.
H2O: 45 mg/mL (182.38 mM), Sonication is recommended.
体内实验配方
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (4.05 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
DMSO/Ethanol/H2O
1mg5mg10mg50mg
1 mM4.0528 mL20.2642 mL40.5285 mL202.6425 mL
5 mM0.8106 mL4.0528 mL8.1057 mL40.5285 mL
10 mM0.4053 mL2.0264 mL4.0528 mL20.2642 mL
20 mM0.2026 mL1.0132 mL2.0264 mL10.1321 mL
Ethanol/H2O
1mg5mg10mg50mg
50 mM0.0811 mL0.4053 mL0.8106 mL4.0528 mL
H2O
1mg5mg10mg50mg
100 mM0.0405 mL0.2026 mL0.4053 mL2.0264 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

VEGFRvasoconstrictionvascular hyperpermeabilityVascular endothelial growth factor receptorTumor Necrosis Factor ReceptorTNFRTNF ReceptorNaphthazolineNaphazoline hydrochlorideNaphazolineInterleukin RelatedInhibitorinhibitinflammatory factorsinflammationdecongestivecytokinesconjunctivitisBeta ReceptorAdrenergicReceptorAdrenergic Receptor
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