规格

价格

库存

数量

1 mg

¥ 295

现货

5 mg

¥ 747

现货

10 mg

¥ 1,160

现货

25 mg

¥ 2,320

现货

50 mg

¥ 3,730

现货

100 mg

¥ 5,450

现货

500 mg

¥ 11,300

现货

1 mL x 10 mM (in DMSO)

¥ 822

现货

生物活性

产品描述	PDE4B-IN-2 (A 33) is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 µM). PDE4B-IN-2 exhibits potent anti-inflammatory effects.
靶点活性	PDE4D:1.7 μM (IC50), PDE4B:15 nM (IC50)
体外活性	PDE4B-IN-2 (compound 33) does not inhibit CYP1A2, CYP3A4, CYP2C9, and CYP2D (IC50>10 µM). PDE4B-IN-2 inhibits LPS-induced TNF-aproduction in vitro from mouseperipheral blood mononuclear cell (PBMC; IC50=0.5 M)[1].
体内活性	PDE4B-IN-2 (compound 33; 2 mg/kg; po) has a Cmax of 8.7 μg/mL and an AUC of 52.3 μg•h/mL in mice[1].
别名	A 33

化学信息

分子量	387.88
分子式	C₁₉H₁₈ClN₃O₂S
CAS No.	915082-52-9
Smiles	CCc1c(C)nc(nc1Nc1ccc(CC(O)=O)cc1)-c1ccc(Cl)s1
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 22.5 mg/mL (58.01 mM), Sonication and heating to 60℃ are recommended.

溶液配制表

DMSO