Utibapril significantly inhibits plasma, renal, and vascular ACE but not ventricular ACE activity. vascular ACE activity significantly inhibited by Utibapril (2 μg/kg/day), and Utibapril (250 μg/kg/day) results in a significant inhibition of plasma ACE.After treatment with the higher doses of utibapril, Furthermore, angiotensin I-induced decreases in coronary flow in the isolated heart are significantly inhibited [1]. FPL 63547 is rapidly and extensively excreted as the diacid in the bile but appeared in the urine in negligible amounts[2].