ML 154

Name: ML 154
Brand: TargetMol
SKU: T22994
Price: 413 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.53%

货号 T22994Cas号 1345964-89-7

ML154 是NPSR 的有效拮抗剂。ML154 在焦虑、成瘾和食物障碍方面具有研究的潜力。

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ML 154

一键复制产品信息

很棒

纯度: 99.53%

货号 T22994Cas号 1345964-89-7

ML154 是NPSR 的有效拮抗剂。ML154 在焦虑、成瘾和食物障碍方面具有研究的潜力。

规格	价格	库存
1 mg	¥ 413	现货
5 mg	¥ 868	现货
10 mg	¥ 1,320	现货
25 mg	¥ 2,320	现货
50 mg	¥ 3,290	现货
100 mg	¥ 4,730	现货
200 mg	¥ 6,590	现货
1 mL x 10 mM (in DMSO)	¥ 987	现货

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COA HNMR LCMS 产品操作手册

产品介绍

ML 154 AI Summary

ML 154 exhibits a diverse range of bioactivities. It demonstrates potent antagonistic effects on the Neuropeptide S receptor, affecting calcium signal transduction with a potency of 0.9381 nM and cAMP signal transduction at 44.5 nM. It inhibits Nrf2 with a potency of 29092.9 nM and TGF-β with potencies of 19952.6 nM and 15848.9 nM. Additionally, it shows high potency in radioligand displacement assays at 1.0 nM and impacts PINK1 expression, PTHR inhibition, and antiviral activity against foot-and-mouth disease virus with potencies from 125892.5 nM to 44668.4 nM. Despite these activities, it shows relatively weak inhibition against Trypanosoma brucei RNA editing ligase 1 (IC50 > 96559.0 nM). ML 154 also modulates beta-arrestin recruitment in various GPCR assays, inhibiting targets including GPR35, AGTR1, FPR2, ADRB2, APLNR, CX3CR1, S1PR1, FFAR4, ADGRF1, C5AR1, and GLP1R with varying degrees of inhibition. It affects the thermal stability of several protein domains, suggesting complex interactions that can both stabilize and destabilize different regions. Furthermore, it exhibits stability in mouse liver microsomes and high brain uptake with a half-life of 8.8 hours. These diverse bioactivities warrant further investigation to elucidate its potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	ML 154 is a potent neuropeptide S receptor (NPSR) antagonist.

化学信息

分子量	545.47
分子式	C₂₉H₂₆BrN₂PS
CAS No.	1345964-89-7
Smiles	CC1=C(P(C2=CC=CC=C2)(C3=CC=CC=C3)=S)[N+]4=CC=CC=C4N1C/C([H])=C([H])/C5=CC=CC=C5.[Br-]
密度	no data available
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (100.83 mM), Sonication is recommended.

Ethanol: < 27.27 mg/mL, Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8333 mL	9.1664 mL	18.3328 mL	91.6641 mL
5 mM	0.3667 mL	1.8333 mL	3.6666 mL	18.3328 mL
10 mM	0.1833 mL	0.9166 mL	1.8333 mL	9.1664 mL
20 mM	0.0917 mL	0.4583 mL	0.9166 mL	4.5832 mL
50 mM	0.0367 mL	0.1833 mL	0.3667 mL	1.8333 mL
100 mM	0.0183 mL	0.0917 mL	0.1833 mL	0.9166 mL