血管生成
EGFR
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Syk
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JAK
(148)
FLT
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VDA
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HER
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FGFR
(94)
BTK
(67)
Bcr-Abl
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ALK
(69)
VEGFR
(199)
FAK
(41)
PDGFR
(108)
HIF
(60)
Src
(112)
凋亡
Caspase
(168)
p53
(70)
Necroptosis
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ASK
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Apoptosis
(1263)
TNF
(247)
RIP kinase
(32)
Mdm2
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IAP
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PD-1/PD-L1
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c-RET
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BCL
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OXPHOS
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FOXO1
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DAPK
(5)
Pyroptosis
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Fas/FasL
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Survivin
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Ferroptosis
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PERK
(25)
自噬
细胞周期
PD-1/PD-L1
(28)
PLK
(32)
ROCK
(55)
Rho
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KSP
(4)
DHFR
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IRE1
(17)
DUB
(55)
Wee1
(8)
Chk
(36)
Aurora Kinase
(68)
c-Myc
(27)
DYRK
(22)
Haspin Kinase
(3)
BMI-1
(6)
LIM Kinase
(8)
Antifolate
(19)
cell cycle arrest
(5)
APC
(8)
Serine/threonin kinase
(44)
Nucleoside Antimetabolite...
(91)
DNA/RNA Synthesis
(306)
CDK
(288)
表观遗传
Histone Demethylase
(65)
HIF/HIF Prolyl-Hydroxylas...
(58)
PARP
(116)
Pim
(27)
Histone Methyltransferase
(155)
Epigenetic Reader Domain
(214)
Sirtuin
(73)
HIF
(60)
JAK
(148)
DNA Methyltransferase
(32)
Aurora Kinase
(68)
Histone Acetyltransferase
(34)
AMPK
(109)
HDAC
(142)
PKC
(133)
Methionine Adenosyltransf...
(8)
PAD
(9)
细胞骨架
Dynamin
(9)
Integrin
(63)
HSP
(91)
PKC
(133)
Gap Junction Protein
(12)
Microtubule Associated
(156)
Myosin
(16)
Akt
(172)
Bcr-Abl
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ROCK
(55)
FAK
(41)
Wnt/beta-catenin
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Arp2/3 Complex
(1)
PAK
(19)
Kinesin
(33)
DNA损伤和修复
Topoisomerase
(141)
DNA Alkylation
(25)
Telomerase
(18)
DNA-PK
(40)
BMI-1
(6)
DNA/RNA Synthesis
(306)
HDAC
(142)
DNA
(24)
PARP
(116)
CRISPR/Cas9
(7)
DNA gyrase
(16)
Nucleoside Antimetabolite...
(91)
DNA Alkylator/Crosslinker
(33)
MTH1
(6)
DHFR
(22)
PPAR
(177)
Sirtuin
(73)
ATM/ATR
(33)
DUB
(55)
内分泌与激素
Oxytocin Receptor
(8)
Estrogen/progestogen Rece...
(130)
Androgen Receptor
(96)
Thyroid hormone receptor(...
(33)
GPR
(130)
Estrogen Receptor/ERR
(115)
Glucocorticoid Receptor
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RAAS
(115)
Opioid Receptor
(135)
Aromatase
(24)
Reductase
(40)
LHRH
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G蛋白偶联受体
Melanocortin Receptor
(25)
Prostaglandin Receptor
(166)
Histamine Receptor
(215)
Adenosine Receptor
(100)
Neuropeptide Y Receptor
(40)
Melatonin Receptor
(10)
Bombesin Receptor
(11)
LPL Receptor
(39)
GHSR
(18)
Amylin Receptor
(3)
GPCR19
(14)
Endothelin Receptor
(26)
TSH Receptor
(4)
Protease-activated Recept...
(34)
Hedgehog/Smoothened
(36)
Neurokinin receptor
(54)
OX Receptor
(23)
Glucagon Receptor
(49)
PAFR
(36)
Neuropeptide W
(1)
CGRP Receptor
(12)
GTPase
(15)
LPA Receptor
(20)
Neurotensin Receptor
(17)
CXCR
(57)
CaSR
(15)
Adrenergic Receptor
(321)
Ras
(95)
5-HT Receptor
(487)
CRFR
(15)
Adiponectin receptor
(4)
Apelin receptor
(10)
Motilin Receptor
(2)
P2Y Receptor
(21)
GPR
(130)
Somatostatin
(16)
Sigma receptor
(38)
EBI2/GPR183
(3)
Cannabinoid Receptor
(80)
Guanylate cyclase
(21)
Bradykinin Receptor
(22)
cAMP
(38)
Leukotriene Receptor
(18)
Dopamine Receptor
(288)
Oxytocin Receptor
(8)
Vasopressin Receptor
(21)
Annexin A
(7)
GNRH Receptor
(23)
cholecystokinin
(22)
SGLT
(31)
S1P Receptor
(45)
GRK
(11)
Melanin-concentrating Hor...
(10)
Opioid Receptor
(135)
免疫与炎症
TLR
(84)
NO Synthase
(105)
Thrombopoietin Receptor
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CD73
(4)
Reactive Oxygen Species
(191)
Cell wall
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Pyroptosis
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cGAS
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IFNAR
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MALT
(6)
gp120/CD4
(7)
Arginase
(8)
NOS
(114)
Histamine Receptor
(215)
Galectin
(5)
IL Receptor
(201)
Complement System
(29)
Aryl Hydrocarbon Receptor
(26)
AIM2
(3)
CD38
(4)
Immunology/Inflammation r...
(50)
COX
(375)
MRP
(26)
LTR
(34)
PGE Synthase
(15)
Nrf2
(75)
NOD-like Receptor (NLR)
(18)
CXCR
(57)
STING
(23)
NADPH-oxidase
(37)
Antiviral
(80)
AhR
(22)
NOD
(28)
ROS
(129)
IRAK
(21)
MyD88
(7)
CCR
(66)
FLAP
(6)
PD-1/PD-L1
(28)
Interleukin
(50)
Prostaglandin Receptor
(166)
JAK/STAT信号通路
MAPK信号通路
S6 Kinase
(37)
TOPK
(7)
Ras
(95)
ERK
(172)
MNK
(8)
Raf
(92)
KLF
(3)
MAPK
(82)
p38 MAPK
(161)
JNK
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MLK
(10)
MEK
(64)
离子通道
Proton pump
(38)
Chloride channel
(34)
CRM1
(8)
Aquaporin
(6)
Calcium Channel
(291)
ABC
(20)
BCRP
(12)
Sodium Channel
(185)
VDAC
(6)
Monoamine Transporter
(14)
Na-K-Cl cotransporter
(5)
Anion Exchanger
(1)
NPC1L1
(7)
Potassium Channel
(245)
iGluR
(98)
OCT
(8)
ATPase
(98)
P-gp
(69)
OAT
(7)
Monocarboxylate transport...
(11)
Na+/Ca2+ Exchanger
(8)
CFTR
(26)
Piezo Channel
(3)
GABA Receptor
(200)
TRP/TRPV Channel
(140)
HCN Channel
(3)
P2X Receptor
(45)
代谢
Phosphorylase
(12)
GSNOR
(2)
Reductase
(40)
Acyltransferase
(29)
Transferase
(57)
NAMPT
(13)
Fatty Acid Synthase
(44)
LDL
(23)
Glucokinase
(36)
N-Acetylglucosaminyltrans...
(1)
Drug Metabolite
(61)
ROR
(33)
hCE
(2)
Angiotensin-converting En...
(6)
Mitochondrial Metabolism
(66)
Phosphatase
(132)
DHFR
(22)
Procollagen C Proteinase
(1)
Glutathione Peroxidase
(24)
PDE
(213)
NUDIX hydrolase
(2)
FXR
(29)
Reactive Oxygen Species
(191)
Carbonic Anhydrase
(50)
Thioredoxin
(1)
AhR
(22)
HIF/HIF Prolyl-Hydroxylas...
(58)
HSP
(91)
Amino Acids and Derivativ...
(40)
Hydrogenase
(1)
Stearoyl-CoA Desaturase (...
(12)
Aminopeptidase
(15)
UGT
(11)
MAGL
(6)
P450
(224)
Liver X Receptor
(22)
ATP Citrate Lyase
(9)
Lipase
(24)
PGC-1α
(2)
HMG-CoA Reductase
(27)
Decarboxylase
(6)
PKM
(10)
Transaminase
(3)
PPAR
(177)
Acetyl-CoA Carboxylase
(11)
Lipid
(18)
Xanthine Oxidase
(24)
Indoleamine 2,3-Dioxygena...
(24)
Taste receptor
(2)
transporter
(41)
NEDD8
(4)
Retinoid Receptor
(50)
IDO
(22)
PAI-1
(12)
Prolyl Endopeptidase (PR...
(2)
Phospholipase
(81)
Isocitrate Dehydrogenase ...
(11)
NADPH
(33)
Endogenous Metabolite
(1237)
RAR/RXR
(5)
Dehydrogenase
(182)
Neprilysin
(9)
Calcium Channel
(291)
Amylase
(7)
Casein Kinase
(50)
FABP
(4)
glycosidase
(1)
Hexokinase
(3)
SGK
(10)
Serine/threonin kinase
(44)
Factor Xa
(24)
stilbene oxidase
(1)
MAO
(88)
FAAH
(33)
aconitase
(1)
Lipoxygenase
(84)
CPT
(2)
CETP
(16)
Hydroxylase
(24)
Adenosine deaminase
(6)
Epoxide Hydrolase
(22)
微生物学
Integrase
(5)
Reverse Transcriptase
(45)
RSV
(17)
Antibiotic
(620)
SARS-CoV
(101)
Influenza Virus
(166)
HIV Protease
(302)
Antifungal
(332)
GluCls
(3)
ribosome
(36)
HBV
(84)
Virus Protease
(84)
Parasite
(319)
CCR
(66)
HSV
(83)
Antifection
(418)
Anti-infection
(67)
Antibacterial
(1074)
HCV Protease
(123)
神经科学
COX
(375)
AChR
(409)
NMU2R
(1)
P-gp
(69)
OX Receptor
(23)
AChE
(112)
NMDAR
(96)
Norepinephrine
(44)
Beta-Secretase
(17)
Neuropeptide W
(1)
iGluR
(98)
Melanocortin Receptor
(25)
5-HT Receptor
(487)
Gamma-secretase
(46)
Histamine Receptor
(215)
GlyT
(12)
BACE
(35)
Monoamine Oxidase
(49)
Neurokinin receptor
(54)
Adrenergic Receptor
(321)
FAAH
(33)
Dopamine Receptor
(288)
GluR
(159)
GABA Receptor
(200)
MT Receptor
(9)
CGRP Receptor
(12)
AAK1 (AP2 associated kina...
(6)
Serotonin Transporter
(43)
MAO
(88)
Neuropeptide Y Receptor
(40)
P2Y Receptor
(21)
Opioid Receptor
(135)
CaMK
(44)
Adenylyl cyclase
(9)
Beta Amyloid
(93)
Adenosine Receptor
(100)
P2X Receptor
(45)
Imidazoline Receptor
(10)
NF-κB信号通路
IκB/IKK
(73)
Reactive Oxygen Species
(191)
NF-κB
(383)
RANKL/RANK
(6)
IRAK
(21)
NOD
(28)
RIP kinase
(32)
氧化还原
PI3K/Akt/mTOR信号通路
PI3K
(265)
DNA-PK
(40)
PTEN
(9)
Akt
(172)
PI4K
(17)
S6 Kinase
(37)
mTOR
(127)
ATM/ATR
(33)
GSK-3
(98)
PDK
(24)
AMPK
(109)
SIK
(7)
MELK
(8)
蛋白酶体
Protease
(2)
Proteasome
(81)
Caspase
(168)
DPP-4
(27)
Prolyl Endopeptidase (PR...
(2)
HCV Protease
(123)
Carboxypeptidase
(7)
Thrombin
(38)
Tyrosinase
(99)
Glutaminase
(8)
MMP
(125)
HIV Protease
(302)
Gamma-secretase
(46)
Cysteine Protease
(49)
Serine Protease
(46)
干细胞
STAT
(122)
ROCK
(55)
Porcupine
(8)
YAP
(16)
Casein Kinase
(50)
GSK-3
(98)
Stemness kinase
(1)
Hippo pathway
(5)
Wnt/beta-catenin
(126)
TGF-beta/Smad
(69)
Smo
(22)
Gamma-secretase
(46)
JAK
(148)
Hedgehog/Smoothened
(36)
蛋白酪氨酸激酶
Src
(112)
PDGFR
(108)
TAM Receptor
(42)
c-Fms
(34)
PYK2
(6)
Syk
(34)
FAK
(41)
PKA
(62)
CSF-1R
(16)
ALK
(69)
Tie-2
(7)
ROS Kinase
(13)
ACK
(5)
DYRK
(22)
Discoidin Domain Receptor...
(12)
FGFR
(94)
EGFR
(236)
FLT
(111)
Bcr-Abl
(71)
Hck
(4)
BTK
(67)
HER
(57)
Ephrin Receptor
(15)
c-Met/HGFR
(83)
VEGFR
(199)
c-RET
(42)
IGF-1R
(52)
Trk receptor
(43)
c-Kit
(83)
Tyrosine Kinases
(55)
泛素化
PROTAC
PROTAC Linker
(171)
ATTECs
(2)
Molecular Glues
(9)
LYTACs
(1)
Ligands for Target Protei...
(11)
PROTACs
(15)
E3 Ligase Ligand-Linker C...
(25)
AUTACs
(1)
Ligand for E3 Ligase
(67)
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