血管生成
ALK
(77)
Bcr-Abl
(80)
BTK
(81)
EGFR
(300)
FAK
(46)
FGFR
(115)
FLT
(114)
HER
(66)
HIF
(66)
JAK
(174)
PDGFR
(109)
Src
(120)
Syk
(38)
VDA
(2)
VEGFR
(231)
凋亡
Cuproptosis
(1)
Apoptosis
(1481)
ASK
(9)
BCL
(157)
c-RET
(44)
Caspase
(193)
DAPK
(7)
Fas/FasL
(3)
Ferroptosis
(119)
FKBP
(2)
FOXO1
(3)
IAP
(23)
Mdm2
(34)
Necroptosis
(8)
OXPHOS
(6)
p53
(74)
PD-1/PD-L1
(66)
PERK
(28)
Pyroptosis
(8)
RIP kinase
(49)
Survivin
(7)
TNF
(257)
自噬
细胞周期
Antifolate
(22)
APC
(8)
Aurora Kinase
(75)
BMI-1
(6)
c-Myc
(32)
CDK
(333)
cell cycle arrest
(5)
Chk
(40)
DHFR
(30)
DNA/RNA Synthesis
(359)
DUB
(64)
DYRK
(26)
Haspin Kinase
(3)
IRE1
(21)
KSP
(4)
LIM Kinase
(11)
Nucleoside Antimetabolite...
(103)
PD-1/PD-L1
(66)
PLK
(35)
Rho
(29)
ROCK
(70)
Serine/threonin kinase
(46)
Wee1
(9)
表观遗传
AMPK
(119)
Aurora Kinase
(75)
DNA Methyltransferase
(34)
Epigenetic Reader Domain
(274)
HDAC
(198)
HIF
(66)
HIF/HIF Prolyl-Hydroxylas...
(68)
Histone Acetyltransferase
(41)
Histone Demethylase
(81)
Histone Methyltransferase
(201)
HuR
(3)
JAK
(174)
Methionine Adenosyltransf...
(10)
PAD
(10)
PARP
(141)
Pim
(35)
PKC
(158)
Sirtuin
(93)
细胞骨架
Akt
(190)
Arp2/3 Complex
(1)
Bcr-Abl
(80)
Dynamin
(9)
FAK
(46)
Gap Junction Protein
(13)
HSP
(106)
Integrin
(92)
Kinesin
(36)
Microtubule Associated
(171)
Myosin
(19)
PAK
(21)
PKC
(158)
ROCK
(70)
Wnt/beta-catenin
(135)
DNA损伤和修复
ATM/ATR
(43)
BMI-1
(6)
CRISPR/Cas9
(8)
DHFR
(30)
DNA
(28)
DNA Alkylation
(29)
DNA Alkylator/Crosslinker
(33)
DNA gyrase
(16)
DNA-PK
(41)
DNA/RNA Synthesis
(359)
DUB
(64)
HDAC
(198)
MTH1
(6)
Nucleoside Antimetabolite...
(103)
PARP
(141)
PPAR
(201)
Sirtuin
(93)
Telomerase
(20)
Topoisomerase
(172)
内分泌与激素
Androgen Receptor
(118)
Aromatase
(24)
Estrogen/progestogen Rece...
(137)
Estrogen Receptor/ERR
(128)
Glucocorticoid Receptor
(88)
GPR
(145)
LHRH
(2)
Opioid Receptor
(157)
Oxytocin Receptor
(17)
RAAS
(123)
Reductase
(49)
Thyroid hormone receptor(...
(35)
G蛋白偶联受体
5-HT Receptor
(567)
Adenosine Receptor
(121)
Adiponectin receptor
(4)
Adrenergic Receptor
(378)
Amylin Receptor
(3)
Annexin A
(7)
Apelin receptor
(12)
Arrestin
(16)
Bombesin Receptor
(15)
Bradykinin Receptor
(24)
cAMP
(45)
Cannabinoid Receptor
(98)
CaSR
(19)
CGRP Receptor
(17)
cholecystokinin
(31)
CRFR
(17)
CXCR
(70)
Dopamine Receptor
(324)
EBI2/GPR183
(3)
Endothelin Receptor
(35)
GHSR
(21)
Glucagon Receptor
(62)
GNRH Receptor
(28)
GPCR19
(16)
GPR
(145)
GRK
(13)
GTPase
(18)
Guanylate cyclase
(25)
Hedgehog/Smoothened
(40)
Histamine Receptor
(245)
Kisspeptin
(4)
Leukotriene Receptor
(33)
LPA Receptor
(23)
LPL Receptor
(45)
Melanin-concentrating Hor...
(10)
Melanocortin Receptor
(35)
Melatonin Receptor
(10)
Motilin Receptor
(3)
MRGPR
(6)
Neurokinin receptor
(64)
Neuropeptide W
(1)
Neuropeptide Y Receptor
(55)
Neurotensin Receptor
(22)
Opioid Receptor
(157)
OX Receptor
(26)
Oxytocin Receptor
(17)
P2Y Receptor
(30)
PACAP
(10)
PAFR
(39)
Prostaglandin Receptor
(183)
Protease-activated Recept...
(35)
Ras
(124)
RXFP receptor
(4)
S1P Receptor
(49)
SGLT
(31)
Sigma receptor
(48)
Somatostatin
(19)
TSH Receptor
(8)
Vasopressin Receptor
(31)
免疫与炎症
AhR
(23)
AIM2
(3)
Antiviral
(126)
Arginase
(12)
Aryl Hydrocarbon Receptor
(27)
CCR
(75)
CD38
(8)
CD73
(8)
Cell wall
(7)
cGAS
(7)
Complement System
(39)
COX
(388)
CXCR
(70)
FKBP
(2)
FLAP
(12)
Galectin
(9)
gp120/CD4
(7)
Histamine Receptor
(245)
IFNAR
(16)
IL Receptor
(220)
Immunology/Inflammation r...
(60)
Interleukin
(61)
IRAK
(32)
LTR
(36)
MALT
(6)
MRP
(26)
MyD88
(7)
NADPH-oxidase
(34)
NO Synthase
(130)
NOD
(35)
NOD-like Receptor (NLR)
(40)
NOS
(120)
Nrf2
(83)
PD-1/PD-L1
(66)
PGE Synthase
(17)
Prostaglandin Receptor
(183)
Pyroptosis
(8)
Reactive Oxygen Species
(222)
ROS
(137)
STING
(37)
Thrombopoietin Receptor
(4)
TLR
(92)
JAK/STAT信号通路
MAPK信号通路
ERK
(191)
JNK
(108)
KLF
(3)
MAPK
(94)
MEK
(70)
MLK
(11)
MNK
(10)
p38 MAPK
(172)
Raf
(101)
Ras
(124)
S6 Kinase
(38)
TOPK
(7)
离子通道
ABC
(22)
Anion Exchanger
(1)
Aquaporin
(6)
ATPase
(103)
BCRP
(15)
Calcium Channel
(349)
CFTR
(32)
Chloride channel
(34)
CRM1
(11)
GABA Receptor
(230)
HCN Channel
(4)
iGluR
(113)
Monoamine Transporter
(16)
Monocarboxylate transport...
(13)
Na-K-Cl cotransporter
(5)
Na+/Ca2+ Exchanger
(10)
NPC1L1
(7)
OAT
(11)
OCT
(8)
P-gp
(73)
P2X Receptor
(54)
Piezo Channel
(3)
Potassium Channel
(300)
Proton pump
(40)
Sodium Channel
(271)
TRP/TRPV Channel
(153)
VDAC
(6)
代谢
Acetyl-CoA Carboxylase
(13)
aconitase
(1)
Acyltransferase
(39)
Adenosine deaminase
(6)
AhR
(23)
Amino Acids and Derivativ...
(43)
Aminopeptidase
(16)
Amylase
(8)
Angiotensin-converting En...
(14)
ATP Citrate Lyase
(11)
Calcium Channel
(349)
Carbonic Anhydrase
(68)
Casein Kinase
(62)
CETP
(15)
CPT
(3)
Decarboxylase
(7)
Dehydrogenase
(204)
DHFR
(30)
Drug Metabolite
(82)
Endogenous Metabolite
(1342)
Epoxide Hydrolase
(24)
FAAH
(39)
FABP
(5)
Factor Xa
(32)
Fatty Acid Synthase
(44)
FXR
(35)
Glucokinase
(42)
Glucosidase
(72)
Glutathione Peroxidase
(29)
glycosidase
(1)
GSNOR
(2)
hCE
(2)
Hexokinase
(4)
HIF/HIF Prolyl-Hydroxylas...
(68)
HMG-CoA Reductase
(32)
HSP
(106)
Hydrogenase
(1)
Hydroxylase
(28)
IDO
(22)
Indoleamine 2,3-Dioxygena...
(30)
Isocitrate Dehydrogenase ...
(13)
LDL
(25)
Lipase
(25)
Lipid
(18)
Liposome
(6)
Lipoxygenase
(103)
Liver X Receptor
(26)
MAGL
(11)
MAO
(97)
Mitochondrial Metabolism
(76)
N-Acetylglucosaminyltrans...
(1)
NADPH
(34)
NAMPT
(15)
NEDD8
(4)
Neprilysin
(10)
NUDIX hydrolase
(2)
P450
(229)
PAI-1
(12)
PDE
(228)
PGC-1α
(3)
Phosphatase
(169)
Phospholipase
(100)
Phosphorylase
(13)
PKM
(12)
PPAR
(201)
Procollagen C Proteinase
(1)
Prolyl Endopeptidase (PR...
(4)
RAR/RXR
(6)
Reactive Oxygen Species
(222)
Reductase
(49)
Retinoid Receptor
(55)
ROR
(36)
Serine/threonin kinase
(46)
SGK
(11)
Stearoyl-CoA Desaturase (...
(13)
stilbene oxidase
(1)
Taste receptor
(2)
Thioredoxin
(1)
Transaminase
(3)
Transferase
(62)
transporter
(47)
UGT
(12)
Vitamin
(3)
Xanthine Oxidase
(31)
微生物学
Anti-infection
(67)
Antibacterial
(1128)
Antibiotic
(715)
Antifection
(402)
Antifungal
(387)
CCR
(75)
GluCls
(3)
HBV
(103)
HCV Protease
(137)
HIV Protease
(333)
HSV
(89)
Influenza Virus
(182)
Integrase
(5)
Parasite
(396)
Reverse Transcriptase
(51)
ribosome
(38)
RSV
(30)
SARS-CoV
(186)
Virus Protease
(112)
神经科学
5-HT Receptor
(567)
AAK1 (AP2 associated kina...
(9)
AChE
(128)
AChR
(439)
Adenosine Receptor
(121)
Adenylyl cyclase
(9)
Adrenergic Receptor
(378)
BACE
(36)
Beta Amyloid
(105)
Beta-Secretase
(20)
CaMK
(47)
CGRP Receptor
(17)
COX
(388)
Dopamine Receptor
(324)
FAAH
(39)
GABA Receptor
(230)
Gamma-secretase
(56)
GluR
(174)
GlyT
(13)
Histamine Receptor
(245)
Huntingtin
(1)
iGluR
(113)
Imidazoline Receptor
(11)
MAO
(97)
Melanocortin Receptor
(35)
Monoamine Oxidase
(74)
MT Receptor
(10)
Neurokinin receptor
(64)
Neuropeptide W
(1)
Neuropeptide Y Receptor
(55)
NMDAR
(114)
NMU2R
(1)
Norepinephrine
(52)
Opioid Receptor
(157)
OX Receptor
(26)
P-gp
(73)
P2X Receptor
(54)
P2Y Receptor
(30)
Serotonin Transporter
(47)
NF-κB信号通路
IRAK
(32)
IκB/IKK
(79)
NF-κB
(412)
NOD
(35)
RANKL/RANK
(7)
Reactive Oxygen Species
(222)
RIP kinase
(49)
氧化还原
PI3K/Akt/mTOR信号通路
Akt
(190)
AMPK
(119)
ATM/ATR
(43)
DNA-PK
(41)
GSK-3
(103)
MELK
(9)
mTOR
(139)
PDK
(25)
PI3K
(291)
PI4K
(19)
PTEN
(10)
S6 Kinase
(38)
SIK
(9)
蛋白酶体
Carboxypeptidase
(9)
Caspase
(193)
Cysteine Protease
(55)
DPP-4
(29)
Gamma-secretase
(56)
Glutaminase
(14)
Glyoxalase
(1)
HCV Protease
(137)
HIV Protease
(333)
MMP
(143)
Prolyl Endopeptidase (PR...
(4)
Protease
(8)
Proteasome
(97)
Serine Protease
(51)
Thrombin
(47)
Tyrosinase
(108)
干细胞
Casein Kinase
(62)
Gamma-secretase
(56)
GSK-3
(103)
Hedgehog/Smoothened
(40)
Hippo pathway
(5)
JAK
(174)
Porcupine
(8)
ROCK
(70)
Smo
(24)
STAT
(140)
Stemness kinase
(1)
TGF-beta/Smad
(85)
Wnt/beta-catenin
(135)
YAP
(26)
蛋白酪氨酸激酶
ACK
(5)
ALK
(77)
Bcr-Abl
(80)
BTK
(81)
c-Fms
(42)
c-Kit
(86)
c-Met/HGFR
(99)
c-RET
(44)
CSF-1R
(18)
Discoidin Domain Receptor...
(12)
DYRK
(26)
EGFR
(300)
Ephrin Receptor
(18)
FAK
(46)
FGFR
(115)
FLT
(114)
Hck
(4)
HER
(66)
IGF-1R
(57)
PDGFR
(109)
PKA
(71)
PYK2
(7)
ROS Kinase
(21)
Src
(120)
Syk
(38)
TAM Receptor
(46)
Tie-2
(9)
Trk receptor
(54)
Tyrosine Kinases
(59)
VEGFR
(231)
泛素化
PROTAC
ATTECs
(2)
AUTACs
(5)
E3 Ligase Ligand-Linker C...
(26)
Ligand for E3 Ligase
(61)
Ligands for Target Protei...
(19)
LYTACs
(10)
Molecular Glues
(13)
PROTAC Linker
(174)
PROTACs
(274)
SNIPERs
(2)
Antibody-drug Conjugate/ADC Related
Antibody-Drug Conjugates ...
(28)
Drug-Linker Conjugates fo...
(228)
ADC Cytotoxin
(179)
ADC Antibody
(32)
PROTAC-Linker Conjugates ...
(2)
ADC Linker
(703)
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