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Abafungin

Name: Abafungin
Brand: TargetMol
SKU: T21448
Price: 188 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 阿巴芬净, UNII-11DI31LWXF, Bay w 6341

货号 T21448Cas号 129639-79-8 一键复制产品信息纯度: 98.11%

很棒

Abafungin (Bay w 6341) 是抗真菌药物，可抑制由 sterol-C-24-methyltransferase 催化的固醇侧链 C-24位点的甲基转移。

Abafungin

一键复制产品信息

很棒

纯度: 98.11%

货号 T21448Cas号 129639-79-8

别名 阿巴芬净, UNII-11DI31LWXF, Bay w 6341

Abafungin (Bay w 6341) 是抗真菌药物，可抑制由 sterol-C-24-methyltransferase 催化的固醇侧链 C-24位点的甲基转移。

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
1 mg	¥ 188	现货
5 mg	¥ 397	现货
10 mg	¥ 653	现货
25 mg	¥ 1,120	现货
50 mg	¥ 1,660	现货
100 mg	¥ 2,380	现货
200 mg	¥ 3,380	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.11%

颜色: 白色

性状: Solid

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Abafungin AI Summary

Abafungin exhibits significant antiviral and antifungal activities. It shows potent inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 μM concentration with an inhibition rate of 92.89% after 48 hours, and a lesser inhibition rate of -0.22% in VERO-6 cells under similar conditions. The compound also moderately inhibits the SARS-CoV-2 3CL-Pro protease with 9.394% inhibition at 20 μM, observed through a FRET assay. For antifungal properties, Abafungin demonstrates activity against Candida albicans with a MIC of 312.5 nM and against Aspergillus fumigatus ATCC 204305 with a MIC value of 2.0 μg/mL. It also shows efficacy against pan-azole resistant Aspergillus fumigatus SR47013 with similar MIC values. However, it does not exhibit antifungal activity against Cryptococcus neoformans, nor does it show antibacterial activity as evidenced by MIC values greater than 20000.0 nM against several bacterial strains. In addition, Abafungin exhibits inhibition of human HDAC6 activity, with 38.23% inhibition using a commercial peptide substrate. It has low hemolytic activity on human red blood cells (HC10 > 20.0 μM) and no cytotoxicity against HEK293 cells (CC50 > 20000.0 nM). The compound shows metabolic stability in human liver microsomes (64.0%) but much lower stability in rat liver microsomes at 0.5 μM. Pharmacokinetic data indicate an unbound fraction of less than 0.001 in Sprague-Dawley rats, a clearance rate of 51.4 mL.min-1.kg-1, and a volume of distribution at steady state of 4.92 L.kg-1..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Abafungin (Bay w 6341) is an antifungal agent with a broad-spectrum.
别名	阿巴芬净, UNII-11DI31LWXF, Bay w 6341

化学信息

分子量	378.49
分子式	C₂₁H₂₂N₄OS
CAS No.	129639-79-8
Smiles	Cc1ccc(Oc2ccccc2-c2csc(NC3=NCCCN3)n2)c(C)c1
密度	1.28g/cm3

储存&溶解度

存储

溶解度信息

DMSO: 38.3 mg/mL (101.19 mM), Sonication is recommended.

H2O: Insoluble

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6421 mL	13.2104 mL	26.4208 mL	132.1039 mL
5 mM	0.5284 mL	2.6421 mL	5.2842 mL	26.4208 mL
10 mM	0.2642 mL	1.3210 mL	2.6421 mL	13.2104 mL
20 mM	0.1321 mL	0.6605 mL	1.3210 mL	6.6052 mL
50 mM	0.0528 mL	0.2642 mL	0.5284 mL	2.6421 mL
100 mM	0.0264 mL	0.1321 mL	0.2642 mL	1.3210 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。