Name: HDAC1/MAO-B-IN-1
Brand: TargetMol
SKU: T60947
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 10,600

6-8周

50 mg

¥ 13,800

6-8周

100 mg

¥ 17,500

6-8周

生物活性

产品描述	HDAC1/MAO-B-IN-1 has the potential to be used in the Alzheimer’s disease research. HDAC1/MAO-B-IN-1 is a potent and selective inhibitor of HDAC1/MAO-B that can cross the blood-brain barrier. The IC50 values of HDAC1/MAO-B-IN-1 for HDAC1 and MAO-B are 21.4 nM and 99.0 nM, respectively [1].
靶点活性	MAO-B:99.0 nM, HDAC1:21.4 nM
体外活性	HDAC1/MAO-B-IN-1 (compound 1f) shows inhibitory activities with IC 50 s of 99.0 nM, 9923.0 nM, 21.4 nM for hMAO-B, hMAO-A, hHDAC1, respectively [1]. HDAC1/MAO-B-IN-1 (50 μM; 24 h) displays neuroprotective and inhibitory activity on ROS production in PC12 cells [1]. Cell Viability Assay [1] Cell Line: PC12 cells Concentration: 50 μM Incubation Time: 24 h Result: Displayed neuroprotective and inhibitory activity on ROS production.
体内活性	HDAC1/MAO-B-IN-1 (20 mg/kg; i.g.) exhibits favorable BBB (blood–brain barrier) permeability [1]. HDAC1/MAO-B-IN-1 (15 mg/kg; i.p.) improves the learning and memory abilities of the ICR mice [1]. Animal Model: 6-8 weeks, ICR male mice [1] Dosage: 20 mg/kg Administration: I.g. Result: Exhibited favorable BBB (blood–brain barrier) permeability. Animal Model: 20-25 g, ICR female mice [1] Dosage: 15 mg/kg Administration: I.p.; 15 consecutive days Result: Improved the learning and memory abilities of the ICR mice.