Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HDAC1/MAO-B-IN-1 具有用于阿尔茨海默病研究的潜力。它是一种有效的、选择性的HDAC1/MAO-B 抑制剂,可以穿过血脑屏障。HDAC1/MAO-B-IN-1 对 HDAC1 和 MAO-B 的IC50值分别为 21.4 nM 和 99.0 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | HDAC1/MAO-B-IN-1 has the potential to be used in the Alzheimer’s disease research. HDAC1/MAO-B-IN-1 is a potent and selective inhibitor of HDAC1/MAO-B that can cross the blood-brain barrier. The IC50 values of HDAC1/MAO-B-IN-1 for HDAC1 and MAO-B are 21.4 nM and 99.0 nM, respectively [1]. |
体外活性 | HDAC1/MAO-B-IN-1 (compound 1f) shows inhibitory activities with IC 50 s of 99.0 nM, 9923.0 nM, 21.4 nM for hMAO-B, hMAO-A, hHDAC1, respectively [1]. HDAC1/MAO-B-IN-1 (50 μM; 24 h) displays neuroprotective and inhibitory activity on ROS production in PC12 cells [1]. Cell Viability Assay [1] Cell Line: PC12 cells Concentration: 50 μM Incubation Time: 24 h Result: Displayed neuroprotective and inhibitory activity on ROS production. |
体内活性 | HDAC1/MAO-B-IN-1 (20 mg/kg; i.g.) exhibits favorable BBB (blood–brain barrier) permeability [1]. HDAC1/MAO-B-IN-1 (15 mg/kg; i.p.) improves the learning and memory abilities of the ICR mice [1]. Animal Model: 6-8 weeks, ICR male mice [1] Dosage: 20 mg/kg Administration: I.g. Result: Exhibited favorable BBB (blood–brain barrier) permeability. Animal Model: 20-25 g, ICR female mice [1] Dosage: 15 mg/kg Administration: I.p.; 15 consecutive days Result: Improved the learning and memory abilities of the ICR mice. |
分子量 | 328.79 |
分子式 | C18H17ClN2O2 |
CAS No. | 2759855-37-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
HDAC1/MAO-B-IN-1 2759855-37-1 Inhibitor inhibitor inhibit