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Abacavir monosulfate

产品编号 T61679 CAS 216699-07-9

Abacavir monosulfate is an orally active, competitive nucleoside reverse transcriptase inhibitor that effectively inhibits HIV replication. Additionally, it exhibits anticancer properties in prostate cancer cell lines, and has the ability to penetrate the blood-brain-barrier and suppress telomerase activity [1] [2] [3].

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Abacavir monosulfate, CAS 216699-07-9

规格	价格/CNY	货期
5 mg	￥ 770	35日内发货
10 mg	￥ 1,470	35日内发货
25 mg	￥ 3,370	35日内发货
50 mg	￥ 5,610	35日内发货

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Abacavir monosulfate 的其他形式现货产品:

Abacavir Abacavir sulfate

其他形式的 Abacavir monosulfate:

Abacavir
现货
Abacavir sulfate
现货

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生物活性

化学信息

存储 & 溶解度

产品描述	Abacavir monosulfate is an orally active, competitive nucleoside reverse transcriptase inhibitor that effectively inhibits HIV replication. Additionally, it exhibits anticancer properties in prostate cancer cell lines, and has the ability to penetrate the blood-brain-barrier and suppress telomerase activity [1] [2] [3].
体外活性	Abacavir (15 and 150 μM, 0-120 h) monosulfate inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines [1]. Abacavir (15 and 150 μM, 18 h) monosulfate significantly reduces cell migration and inhibits cell invasion [1]. Abacavir monsulfate induces fat apoptosis [4]. Cell Proliferation Assay [1] Cell Line: PC3, LNCaP and WI-38 Concentration: 15 and 150 μM Incubation Time: 0, 24, 48, 72 and 96 h Result: Showed a dose-dependent growth inhibition on PC3 and LNCaP. Cell Cycle Analysis [1] Cell Line: PC3 and LNCaP Concentration: 150 μM Incubation Time: 0, 18, 24, 48, 72, 96 and 120 h Result: Caused a very high accumulation of cells in S phase in PC3 and LNCaP cells, and G2/M phase increment was observed in PC3 cells. Cell Migration Assay [1] Cell Line: PC3 and LNCaP Concentration: 15 and 150 μM Incubation Time: 18 h Result: Significantly reduced cell migration. Cell Invasion Assay [1] Cell Line: PC3 and LNCaP Concentration: 15 and 150 μM Incubation Time: 18 h Result: Significantly inhibited cell invision.
体内活性	Abacavir (0-7.5 μg/mL, 100 μL, intrascrotal administration; 100 and 200 mg/kg, p.o.; 4 h) monosulfate dose-dependently promoted thrombus formation [2]. Abacavir (50 mg/kg/d; i.p.; 14 days) monosulfate with 0.1 mg/kg/d Decitabine enhances survival of high-risk medulloblastoma-bearing mice [3]. Animal Model: Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7 tm1Gab /J) [2] Dosage: 2.5, 5 and 7.5 μg/mL, 100 μL or 100 and 200 mg/kg Administration: Intrascrotal or oral administration for 4 h Result: Dose-dependently promoted thrombus formation. Animal Model: NSG TM mice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma [3] Dosage: 50 mg/kg/d with 0.1 mg/kg/d Decitabine Administration: Intraperitoneal injection, daily for 14 days Result: Inhibited tumor growth and enhanced mouse survival.

分子量	384.41
分子式	C14H20N6O5S
CAS No.	216699-07-9

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

计算器

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剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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