BTZO-1

Name: BTZO-1
Brand: TargetMol
SKU: T7845
Price: 198 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.46%

货号 T7845Cas号 99420-15-2

BTZO-1 是一种具有心脏保护活性的抗氧化反应元件激活剂。它可以结合巨噬细胞迁移抑制因子，结合的Kd 值为 68.6 nM，并且其结合需要 N 末端 Pro1。

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BTZO-1

一键复制产品信息

很棒

纯度: 99.46%

货号 T7845Cas号 99420-15-2

BTZO-1 是一种具有心脏保护活性的抗氧化反应元件激活剂。它可以结合巨噬细胞迁移抑制因子，结合的Kd 值为 68.6 nM，并且其结合需要 N 末端 Pro1。

规格	价格	库存
1 mg	¥ 198	现货
5 mg	¥ 503	现货
10 mg	¥ 972	现货
25 mg	¥ 1,960	现货
50 mg	¥ 2,800	现货
100 mg	¥ 3,630	现货
200 mg	¥ 4,930	现货
1 mL x 10 mM (in DMSO)	¥ 557	现货

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产品介绍

BTZO-1 AI Summary

BTZO-1 exhibits a range of bioactivities and interactions across different assays. It demonstrates varied effects on cell viability, indicating both growth inhibition (Growth Rate = 0.0) and promotion (Growth Rate = 1.0) in cell lines such as HEK293T, U2OS, and human fibroblasts. This implies that the compound's influence on cell growth is context-dependent. In thermal shift assays targeting specific protein domains, the compound causes diverse changes in melting temperatures (Delta TM), suggesting complex protein interactions. Additionally, in phenotypic cellular assays, it shows an IC50 value of 16.0 nM for apoptosis inhibition in MEC1.5 cells. Biochemically, BTZO-1 binds selectively to human MIF-His with a Kd value of 68.6 nM, as measured by [83H]-BTZO-1 binding. Furthermore, it exhibits selectivity in various bioactivity assays, showing 36.0% of control in CDK8, 47.0% of control in EIF2AK4, and a Ki value of 934.0 nM in GABRA1 assays. These diverse bioactivities underscore the compound's complex interaction profile and potential for multi-target effects..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity.
靶点活性	MIF:68.6 nM (Kd)

化学信息

分子量	240.28
分子式	C₁₃H₈N₂OS
CAS No.	99420-15-2
Smiles	O=c1nc(sc2ccccc12)-c1ccccn1
密度	1.35 g/cm3 (Predicted)
颜色	White
物理性状	solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 8.33 mg/mL (34.67 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1618 mL	20.8091 mL	41.6181 mL	208.0906 mL
5 mM	0.8324 mL	4.1618 mL	8.3236 mL	41.6181 mL
10 mM	0.4162 mL	2.0809 mL	4.1618 mL	20.8091 mL
20 mM	0.2081 mL	1.0405 mL	2.0809 mL	10.4045 mL