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Anti-PAI-1 Antibody (5Y692)
还可以产品编号 TMAY-00574
Anti-PAI-1 Antibody (5Y692) 是一种 Mouse 抗体，靶向 PAI-1。Anti-PAI-1 Antibody (5Y692) 可用于 ELISA(Cap)。
Anti-PAI-1 Antibody (5Y692)
Anti-PAI-1 Antibody (5Y692)
还可以产品编号 TMAY-00574
Anti-PAI-1 Antibody (5Y692) 是一种 Mouse 抗体，靶向 PAI-1。Anti-PAI-1 Antibody (5Y692) 可用于 ELISA(Cap)。
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| 产品描述 | Anti-PAI-1 Antibody (5Y692) is a Mouse antibody targeting PAI-1. Anti-PAI-1 Antibody (5Y692) can be used in ELISA(Cap). |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 5Y692 |
| 交叉反应 | Human |
| 应用 | ELISA(Cap) |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SerpinE1 / PAI-1 (rh SerpinE1 / PAI-1; TMPY-01474; NP_000593.1; Met1-Pro402). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SerpinE1 and PLANH1, is a secreted glycoprotein that belongs to the serpin family. SerpinE1 is the primary physiological inhibitor of the two plasminogen activators urokinase (uPA) and tissue plasminogen activator (tPA). Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Defects in SerpinE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) which is characterized by abnormal bleeding due to SerpinE1 defect in the plasma. High concentrations of SerpinE1 have been associated with thrombophilia which is an autosomal dominant disorder in which affected individuals are prone to develop serious spontaneous thrombosis. Studies of PAI-1 have contributed significantly to the elucidation of the protease inhibitory mechanism of serpins, which is based on a metastable native state becoming stabilised by insertion of the RCL into the central beta-sheet A and formation of covalent complexes with target proteases. Greater expression of PAI-1 has been associated with increased survival of cells and resistance to apoptosis. PAI-1 appears to influence apoptosis by decreasing cell adhesion (anoikis) as well as its effect on intracellular signaling. PAI-1, in its active state, also binds to the extracellular protein vitronectin. When in complex with its target proteases, it binds with high affinity to endocytosis receptors of the low density receptor family. The mechanisms of PAI-1 overexpression during obesity are complex, and it is conceivable that several inducers are involved at the same time at several sites of synthesis. PAI-1 is also implicated in adipose tissue development. It suggests that PAI-1 inhibitors serve in the control of atherothrombosis. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human SerpinE1 / PAI-1 Protein (TMPY-01474) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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