规格

价格

库存

数量

1 mg

¥ 357

现货

5 mg

¥ 852

现货

10 mg

¥ 1,180

现货

25 mg

¥ 2,020

现货

50 mg

¥ 2,790

现货

100 mg

¥ 3,780

现货

200 mg

¥ 5,180

现货

1 mL x 10 mM (in DMSO)

¥ 708

现货

生物活性

产品描述	SRD5A1-IN-1 is an inhibitor of steroid 5α-reductase type 1 (SRD5A1, IC50 = 1.44 µM). SRD5A1-IN-1 lowers the production of dihydrotestosterone and shows a significant decrease in the SRD5A1 protein expression.
体外活性	在HaCaT细胞中，SRD5A1-IN-1（0.5-2.5 μM）通过双重作用降低SRD5A1蛋白的表达，并调节SRD5A1，这些作用影响SRD5A1蛋白表达水平及SRD5A1酶的活性。SRD5A1-IN-1（0.5-2.5 μM）对SRD5A1的mRNA表达不产生影响，且未显示出显著的细胞毒性[1]。

化学信息

分子量	391.27
分子式	C₁₇H₁₁F₆NO₃
CAS No.	2279077-93-7
Smiles	N(C(/C=C/C1=CC(O)=C(O)C=C1)=O)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 27.5 mg/mL (70.28 mM), Sonication is recommended.

溶液配制表

DMSO