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Harmine hydrochloride

Name: Harmine hydrochloride
Brand: TargetMol
SKU: T2811
Price: 285 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.84%

货号 T2811Cas号 343-27-1

别名 盐酸哈尔明碱, telepathine hydrochloride

Harmine hydrochloride (telepathine hydrochloride) 是一种 DYRK 抑制剂，具有抗癌和抗炎活性。它对5-HT2A 血清素受体具有高亲和力，Ki 值为 397 nM。

Harmine hydrochloride

一键复制产品信息

很棒

纯度: 99.84%

货号 T2811 别名 盐酸哈尔明碱, telepathine hydrochlorideCas号 343-27-1

Harmine hydrochloride (telepathine hydrochloride) 是一种 DYRK 抑制剂，具有抗癌和抗炎活性。它对5-HT2A 血清素受体具有高亲和力，Ki 值为 397 nM。

规格	价格	库存
25 mg	¥ 285	现货
50 mg	¥ 415	现货
100 mg	¥ 671	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.84%

颜色: 白色至黄色

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COA HNMR LCMS 产品操作手册

产品介绍

Harmine hydrochloride AI Summary

Harmine hydrochloride exhibits a broad spectrum of bioactivities, implicating its potential for diverse pharmacological applications. It functions as a potent inhibitor of lipid storage modulators, Nrf2, Histone Lysine Methyltransferase G9a, BAZ2B, Human Flap endonuclease 1 (FEN1), and several enzymes linked to DNA repair and cellular signaling such as RAD54, ELG1-dependent DNA repair, and tyrosyl-DNA phosphodiesterase 1 (TDP1). It also displays moderate potency in targeting chronic active B-cell receptor signaling and Schistosoma Mansoni Peroxiredoxins. The compound shows modulatory effects on RanGTP induced Rango and the activity of kallikrein-7 (K7) zymogen. Additionally, Harmine hydrochloride demonstrates significant inhibitory activity against electric eel acetylcholinesterase (AChE) and horse butyrylcholinesterase (BChE), with inhibition rates of 50.86% and 12.05% respectively at a concentration of 2 mg/ml, indicating potential as a cholinesterase inhibitor. It also exhibits cytotoxicity against human HL cells with an 87.3% activity at 50 µM after 72 hours and showcases antichlamydial activity against Chlamydia pneumoniae K7 infected in HL cells with a 26.0% inhibition rate at 50 µM after 70 hours. Furthermore, the compound induces genotoxicity in human embryonic kidney cells and DNA re-replication in MCF 10a normal breast cells and SW480 colon adenocarcinoma cells. It inhibits cell surface uPA generation, CF-induced NF-kB activation, and delays death in the malaria parasite plastid. Additionally, Harmine hydrochloride has notable antiviral activity by inhibiting Hepatitis C Virus (HCV) and activates ClpP. Overall, Harmine hydrochloride's wide range of bioactivities underscores its potential for extensive therapeutic implications and warrants further investigation..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus.
靶点活性	MNB:149 nM, DYRK1A:33 nM, 5-HT2A receptor:397 nM (Ki), DYRK2:1.9 μM, DYRK1B:166 nM
别名	盐酸哈尔明碱, telepathine hydrochloride

化学信息

分子量	248.71
分子式	C₁₃H₁₃ClN₂O
CAS No.	343-27-1
Smiles	Cl.COc1ccc2c(c1)[nH]c1c(C)nccc21
密度	no data available

储存&溶解度

存储

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 2 mg/mL (8.04 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0207 mL	20.1037 mL	40.2075 mL	201.0374 mL
5 mM	0.8041 mL	4.0207 mL	8.0415 mL	40.2075 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

telepathine Hydrochloride Telepathine Serotonin Receptor Inhibitor inhibit Harmine hydrochloride Harmine GluR1 DYRK2 DYRK1B DYRK1A DYRK Dual specificity tyrosine regulated kinase Dual specificity tyrosine phosphorylation regulated kinase 5-hydroxytryptamine Receptor 5HTReceptor 5-HT Receptor 5HT Receptor

Harmine hydrochloride

Harmine hydrochloride