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Fluorometholone

Name: Fluorometholone
Brand: TargetMol
SKU: T3316
Price: 125 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.15%

货号 T3316Cas号 426-13-1

别名 氟米龙, Oxylone, Fluoromethalone, Delmeson, Cortilet

Fluorometholone (Fluoromethalone) 是合成糖皮质激素，具有抗炎和抗过敏作用。它可用作糖皮质激素受体激动剂，能够用于干眼症的研究。

Fluorometholone

一键复制产品信息

很棒

纯度: 99.15%

货号 T3316 别名 氟米龙, Oxylone, Fluoromethalone, Delmeson, CortiletCas号 426-13-1

Fluorometholone (Fluoromethalone) 是合成糖皮质激素，具有抗炎和抗过敏作用。它可用作糖皮质激素受体激动剂，能够用于干眼症的研究。

规格	价格	库存
2 mg	¥ 125	现货
5 mg	¥ 186	现货
10 mg	¥ 258	现货
25 mg	¥ 413	现货
50 mg	¥ 619	现货
100 mg	¥ 868	现货
1 mL x 10 mM (in DMSO)	¥ 322	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.15%

颜色: 白色

性状: Solid

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Fluorometholone AI Summary

Fluorometholone demonstrates a complex and varied pharmacological profile with significant bioactivities across several biological targets. It is potent in inhibiting aggregate formation in a cell model of Huntington disease (6309.6 nM), modulating miRNAs and activating miR-21 (4.1 nM), acting as an agonist and antagonist of the Hypoxia Response Element Signaling Pathway (10.0 nM each), inhibiting ROR gamma transcriptional activity (1771.1 nM and 446.7 nM), and inhibiting human alpha-Glucosidase as a potential chaperone treatment for Pompe Disease (177.8 nM). Additionally, it inhibits Chronic Active B-Cell Receptor Signaling (446.7 nM), Histone Lysine Methyltransferase G9a (89125.1 nM), Polymerase Kappa (89125.1 nM), and Marburg Virus binding or entry into cells (6513.1 nM). Fluorometholone also demonstrates variable growth inhibition against multiple human tumor cell lines, with GI50 values between 51204.37 nM and 100000.0 nM, and inhibits sodium fluorescein uptake in specific transfected CHO cells by significant percentages. Fluorometholone has a moderate lipophilic nature (LogD7.4 = 2.65), which can influence its bioavailability and cellular permeability. It also functions as a potent glucocorticoid receptor agonist with high affinity and shows affinity for progesterone and androgen receptors, albeit weaker. Importantly, no hepatic side effects are indicated based on DILIps assays. The compound exhibits bioactivity in activating human and rat Pregnane X Receptor (PXR) pathways and inhibition of human BSEP. Furthermore, Fluorometholone shows low bioactivity in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2 at a low MOI and presents conflicting antiviral activity against SARS-CoV-2 in different assay setups. It interacts with several receptors, demonstrating weak binding affinity and activities at concentrations above 10,000.0 nM, reflecting generally low potency towards these targets. Overall, Fluorometholone represents a multifaceted compound with therapeutic potential and diverse bioactive properties across multiple biological pathways and systems..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Fluorometholone (Fluoromethalone) is a corticosteroid, most often used after laser-based refractive surgery. It is marketed under the brand names FML (Allergan) and Flarex (Alcon). Fluorometholone acetate ophthalmic suspension is indicated for use in the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye.
别名	氟米龙, Oxylone, Fluoromethalone, Delmeson, Cortilet

化学信息

分子量	376.46
分子式	C₂₂H₂₉FO₄
CAS No.	426-13-1
Smiles	[H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12C
密度	1.25g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (146.1 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 2.5 mg/mL (6.64 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6563 mL	13.2816 mL	26.5632 mL	132.8162 mL
5 mM	0.5313 mL	2.6563 mL	5.3126 mL	26.5632 mL
10 mM	0.2656 mL	1.3282 mL	2.6563 mL	13.2816 mL
20 mM	0.1328 mL	0.6641 mL	1.3282 mL	6.6408 mL
50 mM	0.0531 mL	0.2656 mL	0.5313 mL	2.6563 mL
100 mM	0.0266 mL	0.1328 mL	0.2656 mL	1.3282 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Inhibitor inhibit glucocorticoids GlucocorticoidReceptor Glucocorticoid Receptor Fluorometholone dry eye corticosteroids

Fluorometholone

Fluorometholone