(R)-3-Hydroxy Midostaurin

Name: (R)-3-Hydroxy Midostaurin
Brand: TargetMol
SKU: T12610
Rating: 4.5 (1 reviews)

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产品编号 T12610Cas号 155848-20-7

别名 (R)-CGP52421

(R)-3-Hydroxy Midostaurin is a potent inhibitor of kinases,is a major metabolite of midostaurin undergoing by the hepatic CYP3A4 enzyme,has the potential for acute myeloid leukemia (AML).

(R)-3-Hydroxy Midostaurin

还可以

产品编号 T12610 别名 (R)-CGP52421Cas号 155848-20-7

(R)-3-Hydroxy Midostaurin is a potent inhibitor of kinases,is a major metabolite of midostaurin undergoing by the hepatic CYP3A4 enzyme,has the potential for acute myeloid leukemia (AML).

规格	价格	库存
25 mg	待询	3-6月
50 mg	待询	3-6月
100 mg	待询	3-6月

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生物活性

产品描述	(R)-3-Hydroxy Midostaurin is a potent inhibitor of kinases,is a major metabolite of midostaurin undergoing by the hepatic CYP3A4 enzyme,has the potential for acute myeloid leukemia (AML).
体外活性	(R)-3-Hydroxy Midostaurin against the ITD and D835Y mutants and low micromolar activity against the wild-type enzyme. The epimeric mixture of metabolites ((R)-3-Hydroxy Midostaurin + (S)-3-Hydroxy Midostaurin) substantially inhibits the proliferation of only the Tel-PDGFRβ (GI50=63 nM), KIT D816V (GI50=320 nM), and FLT3-ITD (GI50=650 nM) BaF3 cell lines, while the wild-type cells are relatively insensitive.
别名	(R)-CGP52421