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ST1936 oxalate 是一种 5-HT6 受体的选择性纳摩尔亲和激动剂,对人5-HT6、5-HT7和 5-HT2B 受体的 Ki 值分别为 13、168 和 245 nM。
ST1936 oxalate 是一种 5-HT6 受体的选择性纳摩尔亲和激动剂,对人5-HT6、5-HT7和 5-HT2B 受体的 Ki 值分别为 13、168 和 245 nM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 10,600 | 1-2周 | |
50 mg | ¥ 13,800 | 1-2周 | |
100 mg | ¥ 17,500 | 1-2周 |
产品描述 | ST1936 oxalate is a selective, nanomolar affinity agonist of 5-HT6 receptor(Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively). |
靶点活性 | α2-adrenergic receptor:300 nM (Ki, human), α2-adrenergic receptor:300 nM (Ki, rat), 5-HT6 receptor:13 nM (Ki), 5-HT2B receptor:245 nM (Ki), α1-adrenoceptor:390 nM (Ki, rat), 5-HT7 receptor (human):168 nM (Ki) |
体外活性 | ST1936 appears to be relatively selective for the 5-HT6 receptors, although it has shown affinity also for 5-HT2B, 5-HT1A, 5-HT7 receptor and α-adrenergic receptors when tested in a broad crossreactivity panel that comprised G-protein-coupled receptors, ion channel binding sites, enzymes, and transporters. |
体内活性 | Extracellular single-unit recordings are performed from putative dopamine-containing neurons in the SNc and VTA of anesthetised rats (Male Sprague-Dawley rats).In the VTA, ST1936 induces either dose-related increases (45% of cells) or decreases in basal activity of these dopaminergic neurons. |
分子量 | 326.78 |
分子式 | C15H19ClN2O4 |
CAS No. | 1782228-83-4 |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。
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