Firocoxib

Name: Firocoxib
Brand: TargetMol
SKU: T7596
Price: 233 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.84%

货号 T7596Cas号 189954-96-9

别名 非罗考昔, ML 1785713

Firocoxib (ML 1785713) 是一种可口服的 COX-2选择性抑制剂，IC50为 0.13 μM。它具有抗炎作用，对 COX-2的选择性比对 COX-1 的选择性高 58 倍，IC50为 7.5 μM。

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Firocoxib

一键复制产品信息

很棒

纯度: 99.84%

货号 T7596 别名 非罗考昔, ML 1785713Cas号 189954-96-9

Firocoxib (ML 1785713) 是一种可口服的 COX-2选择性抑制剂，IC50为 0.13 μM。它具有抗炎作用，对 COX-2的选择性比对 COX-1 的选择性高 58 倍，IC50为 7.5 μM。

规格	价格	库存
1 mg	¥ 233	现货
2 mg	¥ 329	现货
5 mg	¥ 538	现货
10 mg	¥ 828	现货
25 mg	¥ 1,480	现货
50 mg	¥ 2,230	现货
100 mg	¥ 3,330	现货
1 mL x 10 mM (in DMSO)	¥ 417	现货

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COA HNMR LCMS 产品操作手册

产品介绍

Firocoxib AI Summary

Firocoxib exhibits potent inhibition of Prostaglandin G/H synthase 2 activity in human whole blood, with an IC50 value of 140.0 nM, while demonstrating weak inhibition against Prostaglandin G/H synthase 1, with an IC50 value greater than 100000.0 nM. It shows moderate activity in a U937 Microsome COX-1 assay, with an IC50 value of 25000.0 nM. In addition to its anti-inflammatory properties, Firocoxib has shown antiviral activities against SARS-CoV-2. It inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells at a concentration of 10 μM after 48 hours, with an inhibition rate of 3.46%. Against the USA-WA1/2020 strain in HRCE cells, it yielded a hit score of 0.09893 at MOI 0.4 after 96 hours. The compound also inhibits SARS-CoV-2 3CL-Pro protease activity by 0.5656% at a 20μM concentration. However, high content imaging of virus-induced cytotoxicity in VERO-6 cells at 10 μM after 48 hours showed an inhibition of -0.04%. Additionally, Firocoxib exhibits inhibitory activity against human HDAC6, with inhibition percentages of -6.89% and -3.0% in enzymatic assays using commercial and custom peptide substrates, respectively..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Firocoxib (ML 1785713) is a selective non-steroidal inhibitor of cycooxygenase-2 (COX-2) (IC50 of 0.13 μM), with anti-inflammatory for use in dogs and horses.
靶点活性	COX-2:0.13 μM, COX-1:7.5 μM
别名	非罗考昔, ML 1785713

化学信息

分子量	336.4
分子式	C₁₇H₂₀O₅S
CAS No.	189954-96-9
Smiles	O(CC1CC1)C2=C(C(C)(C)OC2=O)C3=CC=C(S(C)(=O)=O)C=C3
密度	1.31 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 47 mg/mL (139.71 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9727 mL	14.8633 mL	29.7265 mL	148.6326 mL
5 mM	0.5945 mL	2.9727 mL	5.9453 mL	29.7265 mL
10 mM	0.2973 mL	1.4863 mL	2.9727 mL	14.8633 mL
20 mM	0.1486 mL	0.7432 mL	1.4863 mL	7.4316 mL
50 mM	0.0595 mL	0.2973 mL	0.5945 mL	2.9727 mL
100 mM	0.0297 mL	0.1486 mL	0.2973 mL	1.4863 mL