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Chlormezanone

Name: Chlormezanone
Brand: TargetMol
SKU: T0715
Price: 129 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 氯美扎酮, 芬那露, Trancopal

货号 T0715Cas号 80-77-3 一键复制产品信息纯度: 99.93%

很棒

Chlormezanone (Trancopal) 是一种非苯二氮卓类药物，用于治疗焦虑症和肌肉痉挛。

Chlormezanone

一键复制产品信息

很棒

纯度: 99.93%

货号 T0715Cas号 80-77-3

别名 氯美扎酮, 芬那露, Trancopal

Chlormezanone (Trancopal) 是一种非苯二氮卓类药物，用于治疗焦虑症和肌肉痉挛。

规格	价格	库存
10 mg	¥ 129	现货
25 mg	¥ 189	现货
50 mg	¥ 263	现货
100 mg	¥ 348	现货
200 mg	¥ 515	现货
1 mL x 10 mM (in DMSO)	¥ 143	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.93%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Chlormezanone AI Summary

Chlormezanone exhibits a diverse range of bioactivities and interactions. It shows potency in modulating Lamin A splicing, inhibiting interactions of thyroid hormone receptor and steroid receptor coregulator 2, and inducing erasure of genomic imprints. It is effective in inhibiting the proliferation of Plasmodium falciparum, modulating human peripheral myelin protein 22, and inhibiting several enzymes including human apurinic/apyrimidinic endonuclease 1, MPP8 chromodomain interactions, histone lysine methyltransferase G9a, mammalian selenoprotein thioredoxin reductase 1, and polymerase Iota. Additionally, it inhibits binding or entry into cells for Lassa virus and blocks entry of Ebola virus, while also enhancing Arylsulfatase A activity. The compound shows potential as an inhibitor of sodium fluorescein uptake in OATP1B3-transfected CHO cells and OATP1B1-transfected CHO cells, with high inhibition percentages of 92.0% and 97.47%, respectively. Chlormezanone demonstrates activity in the FDA HLAED assay related to liver enzyme composite activity and has been assessed for Drug Induced Liver Injury (DILI), being classified as DILI positive. It is associated with various forms of liver toxicity, including acute, cytolytic, and cholestatic liver toxicity, and severe hepatitis, but not with chronic liver diseases or liver tumors. Despite its broad range of bioactivities, Chlormezanone shows low bioactivity in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2. It exhibits antiviral activity against SARS-CoV-2 with an IC50 value greater than 20,000 nM. Additionally, it slightly inhibits human HDAC6 enzyme activity and shows binding affinity towards several receptors such as ADRB2, OPRM1, and HRH2, though with no significant inhibitory effects on most targets at concentration levels tested. The compound's wide spectrum of interactions and bioactivities make it a compound of interest for further pharmacological investigation..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Chlormezanone (Trancopal) is a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.
别名	氯美扎酮, 芬那露, Trancopal

化学信息

分子量	273.74
分子式	C₁₁H₁₂ClNO₃S
CAS No.	80-77-3
Smiles	CN1C(c2ccc(Cl)cc2)S(=O)(=O)CCC1=O
密度	1.2205 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

Ethanol: 6.8 mg/mL (24.84 mM), Sonication is recommended.

DMSO: 27.4 mg/mL (100.09 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (9.13 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6531 mL	18.2655 mL	36.5310 mL	182.6551 mL
5 mM	0.7306 mL	3.6531 mL	7.3062 mL	36.5310 mL
10 mM	0.3653 mL	1.8266 mL	3.6531 mL	18.2655 mL
20 mM	0.1827 mL	0.9133 mL	1.8266 mL	9.1328 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0731 mL	0.3653 mL	0.7306 mL	3.6531 mL
100 mM	0.0365 mL	0.1827 mL	0.3653 mL	1.8266 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。