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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Chlormezanone

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Rating icon 很棒

纯度: 99.93%

货号 T0715Cas号 80-77-3

别名 氯美扎酮, 芬那露, Trancopal

Chlormezanone (Trancopal) 是一种非苯二氮卓类药物，用于治疗焦虑症和肌肉痉挛。

Chlormezanone
其他形式的 “Chlormezanone”:
Chlormezanone (Standard)TMSM-362180-77-3
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Chlormezanone

一键复制产品信息
Rating icon 很棒

纯度: 99.93%

货号 T0715 别名 氯美扎酮, 芬那露, TrancopalCas号 80-77-3

Chlormezanone (Trancopal) 是一种非苯二氮卓类药物，用于治疗焦虑症和肌肉痉挛。

规格价格库存数量
10 mg
¥ 129
现货
25 mg
¥ 189
现货
50 mg
¥ 263
现货
100 mg
¥ 348
现货
200 mg
¥ 515
现货
1 mL x 10 mM (in DMSO)
¥ 143
现货
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实验操作小课堂
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选择批次:
纯度: 99.93%
颜色: 白色
性状: Solid
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产品介绍

Chlormezanone AI Summary
Chlormezanone exhibits a diverse range of bioactivities and interactions. It shows potency in modulating Lamin A splicing, inhibiting interactions of thyroid hormone receptor and steroid receptor coregulator 2, and inducing erasure of genomic imprints. It is effective in inhibiting the proliferation of Plasmodium falciparum, modulating human peripheral myelin protein 22, and inhibiting several enzymes including human apurinic/apyrimidinic endonuclease 1, MPP8 chromodomain interactions, histone lysine methyltransferase G9a, mammalian selenoprotein thioredoxin reductase 1, and polymerase Iota. Additionally, it inhibits binding or entry into cells for Lassa virus and blocks entry of Ebola virus, while also enhancing Arylsulfatase A activity. The compound shows potential as an inhibitor of sodium fluorescein uptake in OATP1B3-transfected CHO cells and OATP1B1-transfected CHO cells, with high inhibition percentages of 92.0% and 97.47%, respectively. Chlormezanone demonstrates activity in the FDA HLAED assay related to liver enzyme composite activity and has been assessed for Drug Induced Liver Injury (DILI), being classified as DILI positive. It is associated with various forms of liver toxicity, including acute, cytolytic, and cholestatic liver toxicity, and severe hepatitis, but not with chronic liver diseases or liver tumors. Despite its broad range of bioactivities, Chlormezanone shows low bioactivity in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2. It exhibits antiviral activity against SARS-CoV-2 with an IC50 value greater than 20,000 nM. Additionally, it slightly inhibits human HDAC6 enzyme activity and shows binding affinity towards several receptors such as ADRB2, OPRM1, and HRH2, though with no significant inhibitory effects on most targets at concentration levels tested. The compound's wide spectrum of interactions and bioactivities make it a compound of interest for further pharmacological investigation..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Chlormezanone (Trancopal) is a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.
别名氯美扎酮, 芬那露, Trancopal
化学信息
分子量273.74
分子式C11H12ClNO3S
CAS No.80-77-3
SmilesCN1C(c2ccc(Cl)cc2)S(=O)(=O)CCC1=O
密度1.2205 g/cm3 (Estimated)
储存&溶解度
存储
溶解度信息
Ethanol: 6.8 mg/mL (24.84 mM), Sonication is recommended.
DMSO: 27.4 mg/mL (100.09 mM), Sonication is recommended.
体内实验配方
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (9.13 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
Ethanol/DMSO
1mg5mg10mg50mg
1 mM3.6531 mL18.2655 mL36.5310 mL182.6551 mL
5 mM0.7306 mL3.6531 mL7.3062 mL36.5310 mL
10 mM0.3653 mL1.8266 mL3.6531 mL18.2655 mL
20 mM0.1827 mL0.9133 mL1.8266 mL9.1328 mL
DMSO
1mg5mg10mg50mg
50 mM0.0731 mL0.3653 mL0.7306 mL3.6531 mL
100 mM0.0365 mL0.1827 mL0.3653 mL1.8266 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

γ-Aminobutyric acid ReceptorTranslocator proteinInhibitorinhibitGamma-aminobutyric acid ReceptorGABAReceptorGABA ReceptorChlormezanone
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