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Chlormezanone

Name: Chlormezanone
Brand: TargetMol
SKU: T0715
Price: 129 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.89%

货号 T0715Cas号 80-77-3

别名 氯美扎酮, 芬那露, Trancopal

Chlormezanone (Trancopal) 是一种非苯二氮卓类药物，用于治疗焦虑症和肌肉痉挛。

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Chlormezanone

一键复制产品信息

很棒

纯度: 99.89%

货号 T0715 别名 氯美扎酮, 芬那露, TrancopalCas号 80-77-3

Chlormezanone (Trancopal) 是一种非苯二氮卓类药物，用于治疗焦虑症和肌肉痉挛。

规格	价格	库存
10 mg	¥ 129	现货
25 mg	¥ 189	现货
50 mg	¥ 263	现货
100 mg	¥ 348	现货
200 mg	¥ 515	现货
1 mL x 10 mM (in DMSO)	¥ 143	现货

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纯度: 99.89%

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资源下载:

COA HNMR HPLC 产品操作手册

产品介绍

Chlormezanone AI Summary

Chlormezanone exhibits a diverse range of bioactivities and interactions. It shows potency in modulating Lamin A splicing, inhibiting interactions of thyroid hormone receptor and steroid receptor coregulator 2, and inducing erasure of genomic imprints. It is effective in inhibiting the proliferation of Plasmodium falciparum, modulating human peripheral myelin protein 22, and inhibiting several enzymes including human apurinic/apyrimidinic endonuclease 1, MPP8 chromodomain interactions, histone lysine methyltransferase G9a, mammalian selenoprotein thioredoxin reductase 1, and polymerase Iota. Additionally, it inhibits binding or entry into cells for Lassa virus and blocks entry of Ebola virus, while also enhancing Arylsulfatase A activity. The compound shows potential as an inhibitor of sodium fluorescein uptake in OATP1B3-transfected CHO cells and OATP1B1-transfected CHO cells, with high inhibition percentages of 92.0% and 97.47%, respectively. Chlormezanone demonstrates activity in the FDA HLAED assay related to liver enzyme composite activity and has been assessed for Drug Induced Liver Injury (DILI), being classified as DILI positive. It is associated with various forms of liver toxicity, including acute, cytolytic, and cholestatic liver toxicity, and severe hepatitis, but not with chronic liver diseases or liver tumors. Despite its broad range of bioactivities, Chlormezanone shows low bioactivity in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2. It exhibits antiviral activity against SARS-CoV-2 with an IC50 value greater than 20,000 nM. Additionally, it slightly inhibits human HDAC6 enzyme activity and shows binding affinity towards several receptors such as ADRB2, OPRM1, and HRH2, though with no significant inhibitory effects on most targets at concentration levels tested. The compound's wide spectrum of interactions and bioactivities make it a compound of interest for further pharmacological investigation..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Chlormezanone (Trancopal) is a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.
别名	氯美扎酮, 芬那露, Trancopal

化学信息

分子量	273.74
分子式	C₁₁H₁₂ClNO₃S
CAS No.	80-77-3
Smiles	CN1C(c2ccc(Cl)cc2)S(=O)(=O)CCC1=O
密度	1.2205 g/cm3 (Estimated)
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: 6.8 mg/mL (24.84 mM), Sonication is recommended.

DMSO: 27.4 mg/mL (100.09 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (9.13 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6531 mL	18.2655 mL	36.5310 mL	182.6551 mL
5 mM	0.7306 mL	3.6531 mL	7.3062 mL	36.5310 mL
10 mM	0.3653 mL	1.8266 mL	3.6531 mL	18.2655 mL
20 mM	0.1827 mL	0.9133 mL	1.8266 mL	9.1328 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0731 mL	0.3653 mL	0.7306 mL	3.6531 mL
100 mM	0.0365 mL	0.1827 mL	0.3653 mL	1.8266 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

γ-Aminobutyric acid Receptor Translocator protein Inhibitor inhibit Gamma-aminobutyric acid Receptor GABAReceptor GABA Receptor Chlormezanone

Chlormezanone

Chlormezanone

Chlormezanone 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

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