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Idazoxan hydrochloride

Name: Idazoxan hydrochloride
Brand: TargetMol
SKU: T0115
Price: 169 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.84%

货号 T0115Cas号 79944-56-2

别名 盐酸咪唑克生, RX 781094

Idazoxan hydrochloride (RX 781094) 是一种 α2-肾上腺素受体拮抗剂，改善帕金森氏病、L-DOPA 引起的运动障碍和实验性帕金森病的运动症状。它也是咪唑啉受体拮抗剂，可竞争性拮抗唑啉样药物的中枢性降压作用。

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Idazoxan hydrochloride

一键复制产品信息

很棒

纯度: 99.84%

货号 T0115 别名 盐酸咪唑克生, RX 781094Cas号 79944-56-2

规格	价格	库存
1 mg	¥ 169	现货
5 mg	¥ 413	现货
10 mg	¥ 662	现货
25 mg	¥ 1,200	现货
50 mg	¥ 1,830	现货
100 mg	¥ 2,730	现货
200 mg	¥ 3,920	现货
1 mL x 10 mM (in DMSO)	¥ 215	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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产品介绍

Idazoxan hydrochloride AI Summary

Idazoxan hydrochloride exhibits a diverse range of bioactivities across various biological systems. It has a LogD value of 0.33 and shows significant antagonistic activity against the Alpha-2 adrenergic receptor with a Kd value of 15.85 nM, while also demonstrating agonistic activity against the Alpha-1 adrenergic receptor with a Kd value of 1584.89 nM. The compound displays selectivity with a ratio of 100.0 towards the Alpha-2 adrenergic receptor over the Alpha-1 receptor. Furthermore, in murine and rat assays, it shows alpha-2 adrenergic receptor agonist activity with a Kd value of 10.47 nM and alpha-1 adrenergic receptor agonist activity with a Kd value of 501.19 nM, respectively, suggesting a selectivity ratio of 50.0 in these models. In terms of antiplasmodial activity, Idazoxan hydrochloride effectively inhibits various strains of Plasmodium falciparum, with IC50 values ranging from 10,000.0 nM to 12,589.25 nM. The compound also affects the proliferation of different lines of Plasmodium falciparum and demonstrates multiple molecular modulations such as Lamin A splicing, JMJD2E inhibition, Tau fibril formation inhibition, and interactions with proteins and receptors like Neuropeptide S Receptor, Jumonji Domain Containing 2E, Histone Lysine Methyltransferase G9a, and BLM, among others. Idazoxan hydrochloride has demonstrated antiviral activity notably against SARS-CoV-2. It inhibits the viability of Vero E6 cells and Caco-2 cells infected with SARS-CoV-2, showing an inhibition index of 1.162 and an inhibition rate of 7.58% at 10 µM after 48 hours, respectively. Additionally, it inhibits the SARS-CoV-2 3CL-Pro protease by 14.22% at a concentration of 20 µM. However, the inhibitive effect on VERO-6 cells cytotoxicity is relatively lower at 0.37% inhibition rate. This multi-target activity underscores Idazoxan hydrochloride’s potential as a therapeutic agent across different disease areas..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Idazoxan hydrochloride (RX 781094) is a benzodioxane-linked imidazole. It has alpha-2 adrenoceptor antagonist activity.
别名	盐酸咪唑克生, RX 781094

化学信息

分子量	240.69
分子式	C₁₁H₁₂N₂O₂·HCl
CAS No.	79944-56-2
Smiles	Cl.C1CN=C(N1)C1COC2=C(O1)C=CC=C2
密度	no data available
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 100 mg/mL (415.47 mM), Sonication and heating are recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (16.62 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1547 mL	20.7736 mL	41.5472 mL	207.7361 mL
5 mM	0.8309 mL	4.1547 mL	8.3094 mL	41.5472 mL
10 mM	0.4155 mL	2.0774 mL	4.1547 mL	20.7736 mL
20 mM	0.2077 mL	1.0387 mL	2.0774 mL	10.3868 mL
50 mM	0.0831 mL	0.4155 mL	0.8309 mL	4.1547 mL
100 mM	0.0415 mL	0.2077 mL	0.4155 mL	2.0774 mL