规格

价格

库存

数量

100 mg

¥ 248

现货

500 mg

¥ 629

现货

生物活性

产品描述	Silymarin is a natural polyphenolic flavonolignan mixture extracted from the seeds of Silybum marianum. It can inhibit tumor cell proliferation and angiogenesis, and improve insulin resistance, thus being widely used in liver disease-related research and adjuvant applications. Studies have shown that silymarin exhibits inhibitory activity against the SARS-CoV-2 main protease, and it has potential research value in the mechanism-related studies of COVID-19.
体外活性	Silymarin的作用机制涉及不同的生化反应，如通过刺激聚合酶I和核糖体RNA基因的转录来增加核糖体RNA合成的速率、阻止α-糖苷环毒素的摄取，以及保护细胞膜免受自由基诱导的损伤。Silymarin还在不同阶段对UVB诱导的癌变展现出显著的保护效果，这可能通过其强大的抗氧化性质实现。
体内活性	Silymarin 的静脉注射LD50分别对于小鼠、大鼠、兔子为391.4 mg/kg、70.1 mg/kg、142.3 mg/kg。
别名	水飞蓟素

化学信息

分子量	482.441
分子式	C₂₅H₂₂O₁₀
CAS No.	65666-07-1
Smiles	COc1cc(ccc1O)C1Oc2ccc(cc2OC1CO)C1Oc2cc(O)cc(O)c2C(=O)C1O
密度	1.527 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 71.00 mg/mL (147.17 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 1.00 mg/mL (2.07 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.50 mg/mL (5.18 mM), Sonication is recommended.

50% PEG300+50% saline: 20.00 mg/mL (41.46 mM), Suspension.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0728 mL	10.3640 mL	20.7279 mL	103.6396 mL

DMSO