Aceclofenac

Name: Aceclofenac
Brand: TargetMol
SKU: T1421
Price: 128 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.87%

货号 T1421Cas号 89796-99-6

别名 醋氯芬酸, Preservex, Airtal

Aceclofenac (Preservex) 是一种可口服的非甾体抗炎药，可用于缓解疼痛、骨关节炎、强直性脊柱炎、类风湿性关节炎的研究。

Aceclofenac

一键复制产品信息

很棒

纯度: 99.87%

货号 T1421 别名 醋氯芬酸, Preservex, AirtalCas号 89796-99-6

Aceclofenac (Preservex) 是一种可口服的非甾体抗炎药，可用于缓解疼痛、骨关节炎、强直性脊柱炎、类风湿性关节炎的研究。

规格	价格	库存
200 mg	¥ 128	现货
500 mg	¥ 200	现货
1 g	¥ 251	现货
5 g	¥ 493	现货
10 g	¥ 726	现货
1 mL x 10 mM (in DMSO)	¥ 251	现货

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纯度: 99.87%

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COA HNMR LCMS 产品操作手册

产品介绍

Aceclofenac AI Summary

Aceclofenac exhibits a wide range of bioactivities and inhibitory effects across various targets. It is a potent inhibitor of Lamin A splicing (44.7 nM), and also inhibits the MLL CXXC domain-DNA interaction (3548.1 nM), Ubiquitin-specific Protease USP2a (3162.3 nM), Cytochrome P450 2C9 (1584.9 nM), and Human Apurinic/apyrimidinic Endonuclease 1 (631.0 nM). It shows efficacy against malarial parasite plastid with potencies of 2.9 nM and 4.1 nM. Additionally, it demonstrates DNA re-replication induction in SW480 colon adenocarcinoma cells (366.3 nM). The compound shows significant liver toxicity, with elevated serum activities of ALT, AST, and alkaline phosphatase, indicating hepatotoxicity. It also affects kidney function and electrolyte balance, hinting at potential nephrotoxic effects. Aceclofenac has a low apparent permeability across the human Caco2 cell membrane (logPapp value of -4.41) and displays varying solubility levels in different conditions, with higher solubility in simulated gastric fluid. Aceclofenac also has antiviral properties, showing moderate activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in Vero-6 and Caco-2 cells, and demonstrating a moderate inhibitory effect on the SARS-CoV-2 3CL-Pro protease (32.95% inhibition at 20µM). Moreover, it exhibits anti-inflammatory activity by inhibiting heat-induced egg albumin denaturation at 31.25 µg/ml. The compound inhibits human bile salt export pump (BSEP) (IC50 of 105,000.0 nM) and multidrug resistance-associated proteins MRP3 and MRP4. It binds to Transthyretin (TTR) in human plasma (IC50 of 170,000.0 nM and Kd of 1,200.0 nM). Other activities include inhibition of Aldose Reductase (IC50 of 1288.0 nM) and Protein Serine/Threonine Kinase ERK2 (IC50 of 5927.0 nM), and moderate inhibitory activity on the human HDAC6 enzyme..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Aceclofenac (Preservex) is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties.
靶点活性	COX-2:3 μM (IC50), COX-1:7.3 μM (IC50)
别名	醋氯芬酸, Preservex, Airtal

化学信息

分子量	354.18
分子式	C₁₆H₁₃Cl₂NO₄
CAS No.	89796-99-6
Smiles	N(C1=C(CC(OCC(O)=O)=O)C=CC=C1)C2=C(Cl)C=CC=C2Cl
密度	1.455 g/cm3

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (155.29 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.65 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8234 mL	14.1171 mL	28.2342 mL	141.1712 mL
5 mM	0.5647 mL	2.8234 mL	5.6468 mL	28.2342 mL
10 mM	0.2823 mL	1.4117 mL	2.8234 mL	14.1171 mL
20 mM	0.1412 mL	0.7059 mL	1.4117 mL	7.0586 mL
50 mM	0.0565 mL	0.2823 mL	0.5647 mL	2.8234 mL
100 mM	0.0282 mL	0.1412 mL	0.2823 mL	1.4117 mL