规格

价格

库存

数量

5 mg

¥ 2,780

35日内发货

10 mg

¥ 4,170

35日内发货

25 mg

¥ 8,930

35日内发货

生物活性

产品描述	Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.
靶点活性	DNA gyrase:1.25 μg/mL, TOPO IV:1.5-2.5 μg/mL
体内活性	平均最大血浆浓度(Cmax)为3.00 ± 1.12 μg/mL，达到最大血浆浓度时间(Tmax)为3.0 ± 2.0小时，24小时内曲线下面积(AUC0-24)为40.7 ± 16.7 μg·h/mL。由于GRNX给药后24小时血浆浓度仍然较高，其半衰期(T1/2)无法计算。Cmax与GRNX每千克体重剂量强烈相关(r = 0.85, P = 0.03)。临床上，GRNX给药后3天内热症状消失，C反应蛋白水平在给药后14天回归正常。一位患者经历了血清转氨酶水平暂时性增加[1]。
动物实验	Six male patients with infections who were undergoing MH received 200 mg GRNX once daily. Blood samples were taken before and at 1, 2, 4, 6, 12, and 24 hours after GRNX administration. Plasma GRNX concentrations were measured using high-performance liquid chromatography[1].
别名	加雷沙星, BMS284756

化学信息

分子量	426.41
分子式	C₂₃H₂₀F₂N₂O₄
CAS No.	194804-75-6
Smiles	C[C@H]1NCc2cc(ccc12)-c1ccc2c(c1OC(F)F)n(cc(C(O)=O)c2=O)C1CC1
密度	1.421g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 2 mg/mL (4.69 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3452 mL	11.7258 mL	23.4516 mL	117.2580 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Garenoxacin