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Nolatrexed

Name: Nolatrexed
Brand: TargetMol
SKU: T4228
Price: 251 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 诺拉曲特

货号 T4228Cas号 147149-76-6 一键复制产品信息纯度: 99.61%

很棒

Nolatrexed 是一种胸苷酸合成酶抑制剂，具有潜在的抗癌活性。

Nolatrexed

一键复制产品信息

很棒

纯度: 99.61%

货号 T4228Cas号 147149-76-6

别名 诺拉曲特

Nolatrexed 是一种胸苷酸合成酶抑制剂，具有潜在的抗癌活性。

规格	价格	库存
1 mg	¥ 251	现货
2 mg	¥ 452	现货
5 mg	¥ 813	现货
10 mg	¥ 1,460	现货
25 mg	¥ 2,430	现货
50 mg	¥ 3,630	现货
100 mg	¥ 5,230	现货
1 mL x 10 mM (in DMSO)	¥ 797	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.61%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Nolatrexed AI Summary

Nolatrexed exhibits broad bioactivity with various mechanisms of action. It inhibits thymidylate synthase in Escherichia coli, Lactobacillus casei, and human cells with Ki values between 15.0 nM and 140.0 nM. It also inhibits the growth of mouse leukemia cells, human lymphoblastic leukemia cells, and human adenocarcinoma cells with IC50 values ranging from 810.0 nM to 3700.0 nM, exhibiting a shift in IC50 in the presence of thymidine. Additionally, it shows inhibitory effects on Histone Lysine Methyltransferase G9a with potencies of 316.2 nM and 11490.9 nM, and on the delayed death of the malarial parasite plastid with potencies of 2133.1 nM and 4775.5 nM. In Schwann cell assays, the compound exhibits potencies of 890.6 nM and 12817.8 nM and induces DNA re-replication in breast and colon cancer cells at 7499.3 nM and 23715.0 nM, respectively. It shows 1.47% inhibition of SARS-CoV-2 3CL-Pro protease at 20µM and inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10µM, with an inhibition percentage of -0.22% after 48 hours. Furthermore, Nolatrexed exhibits moderate inhibitory activity against human HDAC6 with varying inhibition percentages depending on the peptide substrate used. The compound has a calculated CLogP value of 1.83..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity.
别名	诺拉曲特

化学信息

分子量	284.34
分子式	C₁₄H₁₂N₄OS
CAS No.	147149-76-6
Smiles	S(C1=C2C(=CC=C1C)NC(N)=NC2=O)C=3C=CN=CC3
密度	1.46g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 11 mg/mL (38.69 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5169 mL	17.5846 mL	35.1692 mL	175.8458 mL
5 mM	0.7034 mL	3.5169 mL	7.0338 mL	35.1692 mL
10 mM	0.3517 mL	1.7585 mL	3.5169 mL	17.5846 mL
20 mM	0.1758 mL	0.8792 mL	1.7585 mL	8.7923 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。