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Cefazolin

Name: Cefazolin
Brand: TargetMol
SKU: T8390
Price: 158 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.51%

货号 T8390Cas号 25953-19-9

别名 头孢唑啉, 头孢唑林

Cefazolin 是一种头孢类抗生素, 用于多种细菌感染的研究。

Cefazolin

一键复制产品信息

很棒

纯度: 99.51%

货号 T8390 别名 头孢唑啉, 头孢唑林Cas号 25953-19-9

Cefazolin 是一种头孢类抗生素, 用于多种细菌感染的研究。

规格	价格	库存
10 mg	¥ 158	现货
25 mg	¥ 236	现货
50 mg	¥ 332	现货
100 mg	¥ 473	现货
500 mg	¥ 795	现货
1 mL x 10 mM (in DMSO)	¥ 187	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.51%

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

生物活性

产品描述	Cefazolin is a semi-synthetic cephalosporin that has a broad spectrum of antibacterial activity and inhibits the synthesis of bacterial cell walls.
别名	头孢唑啉, 头孢唑林

化学信息

分子量	454.51
分子式	C₁₄H₁₄N₈O₄S₃
CAS No.	25953-19-9
Smiles	[H][C@]12SCC(CSc3nnc(C)s3)=C(N1C(=O)[C@H]2NC(=O)Cn1cnnn1)C(O)=O
密度	2.01g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (550.04 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.26 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2002 mL	11.0009 mL	22.0017 mL	110.0086 mL
5 mM	0.4400 mL	2.2002 mL	4.4003 mL	22.0017 mL
10 mM	0.2200 mL	1.1001 mL	2.2002 mL	11.0009 mL
20 mM	0.1100 mL	0.5500 mL	1.1001 mL	5.5004 mL
50 mM	0.0440 mL	0.2200 mL	0.4400 mL	2.2002 mL
100 mM	0.0220 mL	0.1100 mL	0.2200 mL	1.1001 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

TargetMol AI Summary

Cefazolin exhibits a broad spectrum of bioactivities, including significant antimicrobial activity against a variety of bacterial strains. Its antibacterial efficacy varies widely depending on the strain and resistance profile, with notable activity against methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, Klebsiella pneumoniae, among others. The minimum inhibitory concentrations (MIC) for Cefazolin span from sub-microgram to high micromolar levels, indicating diverse potency across different bacterial targets. Additionally, Cefazolin demonstrates dynamic hydrolysis rates under different pH conditions, with a higher rate of hydrolysis at more alkaline pH values, specifically pH 10 compared to pH 9.6. The compound also shows low binding affinity to the membrane transport protein PEPT1 in human Caco-2 cells and exhibits antiproliferative effects in various human cell lines, including primary human osteoblasts, MG63 cells, and HeLa cells. In terms of pharmacokinetic properties, Cefazolin has a high oral bioavailability of 90% and favorable pharmacokinetics such as a volume of distribution at steady state of 0.1 L.kg-1, and a total body clearance of 0.89 mL.min-1.kg-1, indicating efficient absorption and moderate elimination from the body. The compound also shows significant protein binding in plasma and some degree of renal clearance. Cefazolin has been observed to exhibit moderate liver toxicity during clinical trials, marked by elevated serum enzyme levels. It shows a broad range of activity in various bioassays, including those for transporter inhibition, bacterial efflux pump interactions, and activity against specific metabolic pathways and enzymes in pathogenic organisms. The compound also displays potential antiviral properties, including inhibition of SARS-CoV-2 induced cytotoxicity in VERO-6 cells, albeit at high concentrations. Overall, Cefazolin is characterized by extensive antimicrobial efficacy, dynamic pH-dependent hydrolysis, significant pharmacokinetic attributes, and potential antiviral effects, rendering it a compound of interest for further research and development in antimicrobial and antiviral therapeutics..

Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl