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Bifemelane hydrochloride

Name: Bifemelane hydrochloride
Brand: TargetMol
SKU: T22605
Price: 139 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.93%

货号 T22605Cas号 62232-46-6

Bifemelane hydrochloride 是一种选择性的，有效的，和竞争性的单胺氧化酶A (MAO-A)抑制剂，Ki=4.20 μM，它也非竞争性地抑制MAO-B，Ki=46.0 μM。它具有显著的抗抑郁作用，可用于研究与脑血管疾病有关的认知和情绪障碍。

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Bifemelane hydrochloride

一键复制产品信息

很棒

纯度: 99.93%

货号 T22605Cas号 62232-46-6

规格	价格	库存
1 mg	¥ 139	现货
2 mg	¥ 198	现货
5 mg	¥ 358	现货
10 mg	¥ 597	现货
25 mg	¥ 1,180	现货
50 mg	¥ 1,920	现货
100 mg	¥ 2,800	现货
500 mg	¥ 5,890	现货
1 mL x 10 mM (in DMSO)	¥ 397	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.93%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Bifemelane hydrochloride AI Summary

Bifemelane hydrochloride exhibits a range of bioactivities, including the ability to prevent and reverse reserpine-induced hypothermia in mice with relative potency of 0.78 against amitriptyline and an ED10 of 12.5 mg/kg, respectively. It has an antimuricide effect in olfactory bulb removed rats with an effectiveness of 71.0%, an antiphysostigmine effect with ED50 above 200 mg/kg, and a muscle relaxant effect with ED50 above 200 mg/kg. Toxicity is measured with an LD50 of 1000 mg/kg. Additionally, it reduces histamine-induced contraction with an IC50 of 1.1 µg/mL. The compound shows potent activity in various biological assays, including a potency of 3.5 nM in a qHTS assay for Lamin A splicing modulators, 25118.9 nM in a qHTS assay for inhibitors of Chronic Active B-Cell Receptor Signaling, and 44668.4 nM in a qHTS assay for inhibitors of APE1. Bifemelane hydrochloride also exhibits antiviral activity by inhibiting SARS-CoV-2-induced cytotoxicity in Caco-2 cells with an inhibition rate of 20.31% at 10 µM, and a moderate inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM with 16.25% inhibition. Conversely, its antiviral activity against SARS-CoV-2 in VERO-6 cells shows a minimal inhibition rate of -0.18% at 10 µM. Furthermore, Bifemelane hydrochloride demonstrates antifungal activity against Candida albicans and Cryptococcus neoformans, and antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus MRSA, with the inhibitory effects varying as measured by MIC in CAMBH media using OD readings..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Bifemelane hydrochloride is a MAO inhibitor
靶点活性	MAO-A:4.2 μM (Ki), MAO-B:46 μM (Ki)

化学信息

分子量	305.84
分子式	C₁₈H₂₃NO·HCl
CAS No.	62232-46-6
Smiles	Cl.CNCCCCOc1ccccc1Cc1ccccc1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: < 30.58 mg/mL, Sonication is recommended.

DMSO: 55 mg/mL (179.83 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.54 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2697 mL	16.3484 mL	32.6968 mL	163.4842 mL
5 mM	0.6539 mL	3.2697 mL	6.5394 mL	32.6968 mL
10 mM	0.3270 mL	1.6348 mL	3.2697 mL	16.3484 mL
20 mM	0.1635 mL	0.8174 mL	1.6348 mL	8.1742 mL
50 mM	0.0654 mL	0.3270 mL	0.6539 mL	3.2697 mL
100 mM	0.0327 mL	0.1635 mL	0.3270 mL	1.6348 mL