3-Methylsalicylic acid

Name: 3-Methylsalicylic acid
Brand: TargetMol
SKU: T1423
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 97.36%

货号 T1423Cas号 83-40-9

别名 邻甲基水杨酸, o-Cresotic acid, Hydroxytoluic acid, 3-甲基水杨酸

3-Methylsalicylic acid (o-Cresotic acid) 是水杨酸衍生物，可作用于人血浆，激活纤维蛋白溶解系统，具有显著的纤溶活性。

3-Methylsalicylic acid

一键复制产品信息

很棒

纯度: 97.36%

货号 T1423 别名 邻甲基水杨酸, o-Cresotic acid, Hydroxytoluic acid, 3-甲基水杨酸Cas号 83-40-9

3-Methylsalicylic acid (o-Cresotic acid) 是水杨酸衍生物，可作用于人血浆，激活纤维蛋白溶解系统，具有显著的纤溶活性。

规格	价格	库存	数量
1 g	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 195	现货

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纯度: 97.36%

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产品介绍

3-Methylsalicylic acid AI Summary

3-Methylsalicylic acid exhibits multifaceted bioactivity as an inhibitor across a wide range of biological targets and assays. Specifically, it inhibits human carbonic anhydrase 1 and 2 with IC50 values of 3070000.0 nM and 4700000.0 nM respectively, and shows noncompetitive inhibition for CA1 (Ki = 11420000.0 nM) and uncompetitive inhibition for CA2 (Ki = 10570000.0 nM). It also acts as an inhibitor for various enzymes including HSD17B4, JMJD2E, ALDH1A1, Bacillus subtilis Sfp phosphopantetheinyl transferase, HPGD, Glutaminase, APE1, and human HDAC6. Furthermore, it has antiviral activity, demonstrating 17.75% inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 uM and 8.832% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM. It also inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells, and blocks Ebola virus entry. Additionally, it shows inhibition of recombinant iNOS, various human MMPs, 5-lipoxygenase, and mushroom tyrosinase, with particularly high inhibition of mushroom tyrosinase (96.0% at 1 mM). Notably, 3-Methylsalicylic acid demonstrates toxicity in rats with a pLD50 of 6.1. However, it shows limited inhibition of human IDO1 enzyme (2.0%)..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	3-Methylsalicylic acid (o-Cresotic acid) is a long-acting salicylate derivative with antilipidemic properties. Hydroxytoluic acid has been shown to lower plasma free fatty acid and cholesterol levels.
别名	邻甲基水杨酸, o-Cresotic acid, Hydroxytoluic acid, 3-甲基水杨酸

化学信息

分子量	152.15
分子式	C₈H₈O₃
CAS No.	83-40-9
Smiles	CC1=CC=CC(C(O)=O)=C1O
密度	1.304 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (295.76 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.5725 mL	32.8623 mL	65.7246 mL	328.6231 mL
5 mM	1.3145 mL	6.5725 mL	13.1449 mL	65.7246 mL
10 mM	0.6572 mL	3.2862 mL	6.5725 mL	32.8623 mL
20 mM	0.3286 mL	1.6431 mL	3.2862 mL	16.4312 mL
50 mM	0.1314 mL	0.6572 mL	1.3145 mL	6.5725 mL
100 mM	0.0657 mL	0.3286 mL	0.6572 mL	3.2862 mL