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CX546

Name: CX546
Brand: TargetMol
SKU: T7580
Price: 118 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.75%

货号 T7580Cas号 215923-54-9

别名 苯并二氧六环-6-(1-哌啶基)甲酰胺

CX546 是一种 AMPA 受体调节剂。它增强大鼠的认知功能，具有抗精神病的作用。

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CX546

一键复制产品信息

很棒

纯度: 99.75%

货号 T7580 别名 苯并二氧六环-6-(1-哌啶基)甲酰胺Cas号 215923-54-9

CX546 是一种 AMPA 受体调节剂。它增强大鼠的认知功能，具有抗精神病的作用。

规格	价格	库存
1 mg	¥ 118	现货
5 mg	¥ 257	现货
10 mg	¥ 416	现货
25 mg	¥ 822	现货
50 mg	¥ 1,180	现货
100 mg	¥ 1,780	现货
200 mg	¥ 2,630	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.75%

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COA LCMS HNMR 产品操作手册

产品介绍

CX546 AI Summary

CX546 demonstrates diverse bioactivities across various assays. It is notably an inhibitor of GluR3/4 in rat hippocampal neurons with an EC50 value of 1600 µM. Additionally, it exhibits inhibitory activity against multiple targets, including RecQ-Like DNA Helicase 1, Endonuclease IV, Histone Lysine Methyltransferase G9a, and Mammalian Selenoprotein Thioredoxin Reductase 1. It also shows modulation of lipid storage in Drosophila cells and agonism of the Thyroid Stimulating Hormone Receptor. This compound inhibits T. brucei phosphofructokinase, HP1-beta Chromodomain interactions with methylated histone tails, ELG1-dependent DNA repair, and binding/entry into cells for Lassa Virus. In the context of SARS-CoV-2, CX546 inhibits the SARS-CoV-2 3CL-Pro protease by 21.23% at a concentration of 20 µM and demonstrates antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM with an inhibition rate of 0.02% over 48 hours. The potencies of the compound in various bioassays vary, ranging from nanomolar to micromolar levels..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	CX546 is an AMPA receptor modulator. CX546 enhances cognitive function in rats. It has also been proposed as a treatment for schizophrenia.
别名	苯并二氧六环-6-(1-哌啶基)甲酰胺

化学信息

分子量	247.29
分子式	C₁₄H₁₇NO₃
CAS No.	215923-54-9
Smiles	O=C(N1CCCCC1)c1ccc2OCCOc2c1
密度	1.215g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: 100 mg/mL (404.38 mM), Sonication is recommended.

DMSO: 45 mg/mL (181.97 mM), Sonication is recommended.

H2O: 2 mg/mL (8.09 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.09 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	4.0438 mL	20.2192 mL	40.4384 mL	202.1918 mL
5 mM	0.8088 mL	4.0438 mL	8.0877 mL	40.4384 mL

DMSO/Ethanol

	1mg	5mg	10mg	50mg
10 mM	0.4044 mL	2.0219 mL	4.0438 mL	20.2192 mL
20 mM	0.2022 mL	1.0110 mL	2.0219 mL	10.1096 mL
50 mM	0.0809 mL	0.4044 mL	0.8088 mL	4.0438 mL
100 mM	0.0404 mL	0.2022 mL	0.4044 mL	2.0219 mL