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Orphenadrine hydrochloride
Synonyms: 盐酸邻甲苯海拉明, Mephenamin, Mebedrol货号 T1308Cas号 341-69-5 一键复制产品信息纯度: 99.88%
很棒
很棒Orphenadrine hydrochloride (Mephenamin) 是一种非竞争性的NMDA 受体拮抗剂, Ki=6.0 ± 0.7 μM。
Orphenadrine hydrochloride
一键复制产品信息 很棒纯度: 99.88%
货号 T1308Cas号 341-69-5
别名 盐酸邻甲苯海拉明, Mephenamin, Mebedrol
Orphenadrine hydrochloride (Mephenamin) 是一种非竞争性的NMDA 受体拮抗剂, Ki=6.0 ± 0.7 μM。
其他形式的 “Orphenadrine hydrochloride”:
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 mg | ¥ 279 | 现货 | |
| 10 mg | ¥ 393 | 现货 | |
| 25 mg | ¥ 659 | 现货 | |
| 50 mg | ¥ 978 | 现货 | |
| 100 mg | ¥ 1,450 | 现货 | |
| 200 mg | ¥ 2,150 | 现货 | |
| 500 mg | ¥ 3,630 | 现货 | |
| 1 g | ¥ 5,250 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 323 | 现货 |
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产品介绍
Orphenadrine hydrochloride AI Summary
Orphenadrine hydrochloride exhibits a range of bioactivities, demonstrating antiplasmodial activity against various Plasmodium falciparum strains, with IC50 values ranging from 630.96 nM to 11220.2 nM. It shows efficacy in inhibiting the growth of infected Vero E6 cells with SARS-CoV-2, with an inhibition index of 0.9732. The compound also modulates Lamin A splicing, induces erasure of genomic imprints, and inhibits Bloom's syndrome helicase. Furthermore, it acts as an antagonist of the Neuropeptide S receptor and inhibits several enzymes and receptors, including thyroid hormone receptor beta, Histone Lysine Methyltransferase G9a, Mammalian Selenoprotein Thioredoxin Reductase 1, human hERG channel activity, and human Apurinic/apyrimidinic Endonuclease 1. It induces DNA re-replication in MCF 10a normal breast cells and shows activity against Hepatitis C Virus. Additionally, Orphenadrine hydrochloride exhibits moderate antifungal activity against Candida albicans and varying antibacterial activities, ranging from weak to strong inhibition against multiple bacterial strains, including moderate to strong inhibition against Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus MRSA..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Orphenadrine hydrochloride (Mephenamin) is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. |
| 靶点活性 | NMDAR:6.0 ±0.7 μM (Ki) |
| 别名 | 盐酸邻甲苯海拉明, Mephenamin, Mebedrol |
| 分子量 | 305.85 |
| 分子式 | C18H23NO·HCl |
| CAS No. | 341-69-5 |
| Smiles | Cl.CN(C)CCOC(c1ccccc1)c1ccccc1C |
| 密度 | 1.014g/cm3 |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准 | |||||||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 45 mg/mL (147.13 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。 | ||||||||||||||||||||||||||||||||||||
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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