Orphenadrine hydrochloride

Name: Orphenadrine hydrochloride
Brand: TargetMol
SKU: T1308
Price: 279 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.88%

货号 T1308Cas号 341-69-5

别名 盐酸邻甲苯海拉明, Mephenamin, Mebedrol

Orphenadrine hydrochloride (Mephenamin) 是一种非竞争性的NMDA 受体拮抗剂, Ki=6.0 ± 0.7 μM。

Orphenadrine hydrochloride

一键复制产品信息

很棒

纯度: 99.88%

货号 T1308 别名 盐酸邻甲苯海拉明, Mephenamin, MebedrolCas号 341-69-5

Orphenadrine hydrochloride (Mephenamin) 是一种非竞争性的NMDA 受体拮抗剂, Ki=6.0 ± 0.7 μM。

规格	价格	库存
5 mg	¥ 279	现货
10 mg	¥ 393	现货
25 mg	¥ 659	现货
50 mg	¥ 978	现货
100 mg	¥ 1,450	现货
200 mg	¥ 2,150	现货
500 mg	¥ 3,630	现货
1 g	¥ 5,250	现货
1 mL x 10 mM (in DMSO)	¥ 323	现货

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纯度: 99.88%

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产品介绍

Orphenadrine hydrochloride AI Summary

Orphenadrine hydrochloride exhibits a range of bioactivities, demonstrating antiplasmodial activity against various Plasmodium falciparum strains, with IC50 values ranging from 630.96 nM to 11220.2 nM. It shows efficacy in inhibiting the growth of infected Vero E6 cells with SARS-CoV-2, with an inhibition index of 0.9732. The compound also modulates Lamin A splicing, induces erasure of genomic imprints, and inhibits Bloom's syndrome helicase. Furthermore, it acts as an antagonist of the Neuropeptide S receptor and inhibits several enzymes and receptors, including thyroid hormone receptor beta, Histone Lysine Methyltransferase G9a, Mammalian Selenoprotein Thioredoxin Reductase 1, human hERG channel activity, and human Apurinic/apyrimidinic Endonuclease 1. It induces DNA re-replication in MCF 10a normal breast cells and shows activity against Hepatitis C Virus. Additionally, Orphenadrine hydrochloride exhibits moderate antifungal activity against Candida albicans and varying antibacterial activities, ranging from weak to strong inhibition against multiple bacterial strains, including moderate to strong inhibition against Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus MRSA..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Orphenadrine hydrochloride (Mephenamin) is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
靶点活性	NMDAR:6.0 ±0.7 μM (Ki)
别名	盐酸邻甲苯海拉明, Mephenamin, Mebedrol

化学信息

分子量	305.85
分子式	C₁₈H₂₃NO·HCl
CAS No.	341-69-5
Smiles	Cl.CN(C)CCOC(c1ccccc1)c1ccccc1C
密度	1.014g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (147.13 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2696 mL	16.3479 mL	32.6958 mL	163.4788 mL
5 mM	0.6539 mL	3.2696 mL	6.5392 mL	32.6958 mL
10 mM	0.3270 mL	1.6348 mL	3.2696 mL	16.3479 mL
20 mM	0.1635 mL	0.8174 mL	1.6348 mL	8.1739 mL
50 mM	0.0654 mL	0.3270 mL	0.6539 mL	3.2696 mL
100 mM	0.0327 mL	0.1635 mL	0.3270 mL	1.6348 mL