Moxifloxacin

Name: Moxifloxacin
Brand: TargetMol
SKU: T0331L
Price: 298 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.99%

货号 T0331LCas号 151096-09-2

别名 莫西沙星, Moxeza, Avelox

Moxifloxacin (Avelox) 是一种8-甲氧基喹诺酮类口服有效抗菌药物，用于急性细菌性鼻窦炎，慢性支气管炎的急性细菌性加重和感染性肺炎的研究。

Moxifloxacin

一键复制产品信息

很棒

纯度: 99.99%

货号 T0331L 别名 莫西沙星, Moxeza, AveloxCas号 151096-09-2

Moxifloxacin (Avelox) 是一种8-甲氧基喹诺酮类口服有效抗菌药物，用于急性细菌性鼻窦炎，慢性支气管炎的急性细菌性加重和感染性肺炎的研究。

规格	价格	库存	数量
50 mg	¥ 298	现货
100 mg	¥ 418	现货

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产品介绍

Moxifloxacin AI Summary

Moxifloxacin exhibits broad-spectrum antimicrobial activity against a variety of bacterial strains, including methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, Streptococcus pneumoniae, and Mycobacterium tuberculosis. It demonstrates potent inhibitory effects with low minimum inhibitory concentration (MIC) values, ranging from 0.003 to 64.0 µg/mL for various bacteria. Additionally, Moxifloxacin shows effectiveness against antibiotic-resistant strains such as penicillin-resistant Streptococcus pneumoniae, vancomycin-resistant enterococci (VRE), and fluoroquinolone-resistant bacteria. Pharmacokinetic studies in humans reveal good oral bioavailability (up to 90%), favorable plasma concentrations, and moderate hepatic and renal clearances. The compound also exhibits inhibition of human ERG and potassium channels with IC50 values around 117,000 to 129,000 nM, indicating potential cardiotoxicity. Cytotoxicity assays show low impact on human Hep2 cells with a CC50 > 100,000 nM, suggesting a high therapeutic index. Moxifloxacin has shown promising results in vivo, reducing bacterial loads in infected animal models of tuberculosis and other infections. Overall, its broad-spectrum activity, including against multidrug-resistant strains, and favorable pharmacokinetic profile, makes Moxifloxacin a promising candidate for further development as a potent antimicrobial agent..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Moxifloxacin (Avelox) is a fourth-generation fluoroquinolone that has been shown to be effective against Gram-positive, Gram-negative, and atypical strains, as well as multi-drug resistant Streptococcus pneumoniae.
别名	莫西沙星, Moxeza, Avelox

化学信息

分子量	401.43
分子式	C₂₁H₂₄FN₃O₄
CAS No.	151096-09-2
Smiles	O(C)C1=C2N(C=C(C(O)=O)C(=O)C2=CC(F)=C1N3C[C@]4([C@@](C3)(NCCC4)[H])[H])C5CC5
密度	1.408 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 19.23 mg/mL (47.9 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.22 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4911 mL	12.4555 mL	24.9109 mL	124.5547 mL
5 mM	0.4982 mL	2.4911 mL	4.9822 mL	24.9109 mL
10 mM	0.2491 mL	1.2455 mL	2.4911 mL	12.4555 mL
20 mM	0.1246 mL	0.6228 mL	1.2455 mL	6.2277 mL