Name: Kallikrein 5/KLK5 Protein, Mouse, Recombinant (His)
Brand: TargetMol
SKU: TMPK-01158
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 μg

¥ 313

3日内发货

10 μg

¥ 498

3日内发货

20 μg

¥ 793

3日内发货

50 μg

¥ 1,580

3日内发货

100 μg

¥ 2,660

现货

200 μg

¥ 4,790

5日内发货

500 μg

¥ 10,600

5日内发货

生物活性

产品描述	The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulation of the endogenous inhibitor LEKTI-1 and profound skin-barrier defects with severe allergic manifestations. To aid in the development of a medicine for this target, an X-ray crystallographic system was developed to facilitate fragment-guided chemistry and knowledge-based drug-discovery approaches.
生物活性	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
研究背景	The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulation of the endogenous inhibitor LEKTI-1 and profound skin-barrier defects with severe allergic manifestations. To aid in the development of a medicine for this target, an X-ray crystallographic system was developed to facilitate fragment-guided chemistry and knowledge-based drug-discovery approaches.
种属	Mouse
表达系统	HEK293 Cells
标签	C-His
蛋白编号	Q9D140
蛋白构建	Gly30-Asn293
蛋白纯度	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM NaAc, 150 mM NaCl (pH 5.0). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
复溶方法	Reconstitute the lyophilized protein in 20mM NaAc, 150mM NaCl (pH 5.0). The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名	SCTE, Klnc, KLK-L2, KLKL2, KLK5, Kallikrein c
内毒素	< 1 EU/μg by the LAL method.

化学信息

分子量	29.9 kDa (predicted). Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.

储存&溶解度

运输方式	In general, Lyophilized powders are shipping with blue ice.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Kallikrein 5/KLK5 Protein, Mouse, Recombinant (His)

Kallikrein 5/KLK5 Protein, Mouse, Recombinant (His)

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