IDO1-IN-1

Name: IDO1-IN-1
Brand: TargetMol
SKU: T20513
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.36%

货号 T20513Cas号 615-21-4

别名 IDO1-inhibitor-1, IDO1IN1, IDO1 inhibitor 1, 2-肼基苯并噻唑, 2-HzBTZ, 2 HzBTZ

IDO1-IN-1 (2 HzBTZ) 是一种吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂。

IDO1-IN-1

一键复制产品信息

很棒

纯度: 99.36%

货号 T20513 别名 IDO1-inhibitor-1, IDO1IN1, IDO1 inhibitor 1, 2-肼基苯并噻唑, 2-HzBTZ, 2 HzBTZCas号 615-21-4

IDO1-IN-1 (2 HzBTZ) 是一种吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂。

规格	价格	库存	数量
200 mg	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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产品介绍

IDO1-IN-1 AI Summary

IDO1-IN-1 exhibits notable bioactivity across multiple domains. It demonstrates antitubercular activity against Mycobacterium tuberculosis H37Rv with a minimum inhibitory concentration (MIC) of 287.5 µg/mL after 7 days, as determined by the Resazurin microtiter assay. In addition, the compound shows significant growth inhibition across various human tumor cell lines, including breast, renal, lung, leukemia, central nervous system, melanoma, prostate, ovarian, and colon cancer cell lines, with a GI50 value of 100,000 nM in most cases. However, it exhibits stronger inhibitory activity in some leukemia and breast cancer cell lines such as MOLT-4, SR, and T-47D, where the GI50 values are slightly lower. Furthermore, IDO1-IN-1 acts as an inhibitor of the enzyme indoleamine 2,3-dioxygenase 1 (IDO1), affecting both mouse and human IDO1 expressed in various cell lines and bacterial models by reducing L-tryptophan metabolism. It shows IC50 values ranging from 50,500 nM to 8,000 nM, with significant inhibition of IDO1 activity up to 91%. These findings suggest that IDO1-IN-1 holds potential as both an antitubercular and anti-cancer agent, and as an IDO1 inhibitor in various biological contexts..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	IDO1-IN-1 (2 HzBTZ) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
靶点活性	IDO1:8 μM
别名	IDO1-inhibitor-1, IDO1IN1, IDO1 inhibitor 1, 2-肼基苯并噻唑, 2-HzBTZ, 2 HzBTZ

化学信息

分子量	165.22
分子式	C₇H₇N₃S
CAS No.	615-21-4
Smiles	NN=C1NC2=CC=CC=C2S1
密度	1.463 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (363.15 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0525 mL	30.2627 mL	60.5254 mL	302.6268 mL
5 mM	1.2105 mL	6.0525 mL	12.1051 mL	60.5254 mL
10 mM	0.6053 mL	3.0263 mL	6.0525 mL	30.2627 mL
20 mM	0.3026 mL	1.5131 mL	3.0263 mL	15.1313 mL
50 mM	0.1211 mL	0.6053 mL	1.2105 mL	6.0525 mL
100 mM	0.0605 mL	0.3026 mL	0.6053 mL	3.0263 mL