规格

价格

库存

数量

1 mg

¥ 390

现货

5 mg

¥ 783

现货

10 mg

¥ 1,230

现货

25 mg

¥ 2,300

现货

50 mg

¥ 3,430

现货

100 mg

¥ 4,530

现货

200 mg

¥ 6,110

现货

1 mL x 10 mM (in DMSO)

¥ 826

现货

生物活性

产品描述	AT-533 is a potent inhibitor of Hsp90 and HSV. AT-533 blocks the HIF-1α/VEGF/VEGFR-2 signaling pathway, leading to suppress tumor growth and angiogenesis. AT-533 also inhibits the activation of the downstream pathways, including Erk1/2, FAK, Akt/mTOR/p70S6K,. AT-533 inhibits the cell migration, invasion, and the tube formation of human umbilical vein endothelial cells (HUVECs).
体外活性	AT-533 (0-1350 nM; 24h or 48h) inhibits 20ng/mL VEGF induced tube formation, cell migration and HUVEC invasion. AT-533 (2 μ M or 75 μ M; 24 h) inhibits HIF-1 α/ VEGF in hypoxia induced breast cancer cells signaling pathway and inhibits Akt/mTOR/p70S6K, Erk1/2, and FAK phosphorylation. AT-533 (10 nM, 50 nM; 48 h) exhibits anti angiogenic ability on the chorionic villus (CAM) model [1]. AT-533 (0.5 μ M; 2 hours, 4 hours) reduces TNF induced by HSV-1 in RAW264.7 and BV2 cells- α、 IL-1 β and the production of IL-6 [2].
体内活性	AT-533 (10 mg/kg; intraperitoneal injection; once a day for 21 days) inhibited the expression of HIF-1 α/ VEGF signaling pathway related proteins in mouse MDA-MB-231 xenograft model of breast cancer [1]. AT-533 (1, 2, 4 mg/kg; intraperitoneal injection; once a day for 30 days) did not cause death, appetite loss, weight loss, or adverse reactions in subacute toxicity tests of Sprague Dawley rats [3].

化学信息

分子量	410.51
分子式	C₂₃H₃₀N₄O₃
CAS No.	908112-37-8
Smiles	Cc1nn(c2CC(C)(C)CC(=O)c12)-c1ccc(C(N)=O)c(N[C@H]2CC[C@H](O)CC2)c1
密度	1.36 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 60 mg/mL (146.16 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.87 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4360 mL	12.1800 mL	24.3599 mL	121.7997 mL
5 mM	0.4872 mL	2.4360 mL	4.8720 mL	24.3599 mL
10 mM	0.2436 mL	1.2180 mL	2.4360 mL	12.1800 mL
20 mM	0.1218 mL	0.6090 mL	1.2180 mL	6.0900 mL
50 mM	0.0487 mL	0.2436 mL	0.4872 mL	2.4360 mL
100 mM	0.0244 mL	0.1218 mL	0.2436 mL	1.2180 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

AT-533

AT-533

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

AT-533

AT-533

AT-533 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词