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2,4-Diamino-6-hydroxypyrimidine

Name: 2,4-Diamino-6-hydroxypyrimidine
Brand: TargetMol
SKU: T7461
Price: 195 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.82%

货号 T7461Cas号 56-06-4

别名 DAHP, 2,4-二氨基-6-羟基嘧啶

2,4-Diamino-6-hydroxypyrimidine (DAHP) 是GTP cyclohydrolase I(蛋白从头合成中的限速酶) 的选择性抑制剂。它能够抑制NO 的产生以及阻断 Tetrahydrobiopterin (BH4) 的合成。

为众多的药物研发团队赋能，

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2,4-Diamino-6-hydroxypyrimidine

一键复制产品信息

很棒

纯度: 99.82%

货号 T7461 别名 DAHP, 2,4-二氨基-6-羟基嘧啶Cas号 56-06-4

2,4-Diamino-6-hydroxypyrimidine (DAHP) 是GTP cyclohydrolase I(蛋白从头合成中的限速酶) 的选择性抑制剂。它能够抑制NO 的产生以及阻断 Tetrahydrobiopterin (BH4) 的合成。

规格	价格	库存
25 mg	¥ 198	现货
50 mg	¥ 289	现货
100 mg	¥ 413	现货
500 mg	¥ 662	现货
1 g	¥ 859	现货
2 g	¥ 1,270	现货
1 mL x 10 mM (in DMSO)	¥ 195	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

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纯度: 99.82%

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COA LCMS HNMR 产品操作手册

产品介绍

2,4-Diamino-6-hydroxypyrimidine AI Summary

2,4-Diamino-6-hydroxypyrimidine exhibits a variety of bioactivities, including significant inhibition of several enzymes and biological processes. It displays potency in inhibiting mitochondrial division and activating mitochondrial fusion, as well as in inhibiting the internalization of Anthrax lethal toxin. Furthermore, it inhibits AmpC Beta-Lactamase, Bloom's syndrome helicase (BLM), and mammalian selenoprotein thioredoxin reductase 1 (TrxR1), and it also activates Cytochrome P450 3A4. The compound modulates lipid storage and inhibits T. brucei phosphofructokinase. Additionally, it shows inhibitory activity in the cytochrome panel assay, particularly with p450-cyp3a4, and inhibits binding or entry into cells for Marburg Virus and human tyrosyl-DNA phosphodiesterase 1 (TDP1). It also exhibits activity in blocking entry of Ebola Virus in different screening channels. Furthermore, it moderately inhibits human recombinant MMP3, MMP8, and MMP9 (ranging from 2.0% to 14.0% inhibition after 30 mins), significantly inhibits human recombinant 5-lipoxygenase (65.0% inhibition after 10 mins), and inhibits mushroom tyrosinase by 18.0% after 10 mins. It also shows a substantial inhibitory effect on recombinant anthrax lethal factor (34.0% inhibition after 30 mins) with lower inhibitory activity against MMP1 (3.0%) and MMP2 (6.0%) after 30 mins..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	2,4-Diamino-6-hydroxypyrimidine (DAHP) (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis
别名	DAHP, 2,4-二氨基-6-羟基嘧啶

化学信息

分子量	126.12
分子式	C₄H₆N₄O
CAS No.	56-06-4
Smiles	NC1=NC(N)=CC(=O)N1
密度	1.3659 g/cm3 (Estimated)
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (475.74 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (7.93 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.9290 mL	39.6448 mL	79.2896 mL	396.4478 mL
5 mM	1.5858 mL	7.9290 mL	15.8579 mL	79.2896 mL
10 mM	0.7929 mL	3.9645 mL	7.9290 mL	39.6448 mL
20 mM	0.3964 mL	1.9822 mL	3.9645 mL	19.8224 mL
50 mM	0.1586 mL	0.7929 mL	1.5858 mL	7.9290 mL
100 mM	0.0793 mL	0.3964 mL	0.7929 mL	3.9645 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

VCAM-1 ReactiveOxygenSpecies Reactive Oxygen Species NOSynthase NOS NO Synthase Nitric oxide synthases NF-κB Inhibitor inhibit GTP cyclohydrolase I GTP cyclohydrolase-I BH4 2,4-Diamino-6-hydroxypyrimidine 2,4Diamino6hydroxypyrimidine 2,4 Diamino 6 hydroxypyrimidine

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2,4-Diamino-6-hydroxypyrimidine

2,4-Diamino-6-hydroxypyrimidine