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Tiamulin

Name: Tiamulin
Brand: TargetMol
SKU: T8065
Price: 137 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.85%

货号 T8065Cas号 55297-95-5

别名 泰妙菌素, Thiamutilin

Tiamulin (Thiamutilin) 是一类二萜，广泛用于控制猪的传染疾病，包括猪痢疾和地方性肺炎等。

Tiamulin

一键复制产品信息

很棒

纯度: 99.85%

货号 T8065 别名 泰妙菌素, ThiamutilinCas号 55297-95-5

Tiamulin (Thiamutilin) 是一类二萜，广泛用于控制猪的传染疾病，包括猪痢疾和地方性肺炎等。

规格	价格	库存
25 mg	¥ 137	现货
50 mg	¥ 186	现货
100 mg	¥ 258	现货
500 mg	¥ 582	现货
1 g	¥ 828	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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实验操作小课堂

常见问题解答

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纯度: 99.85%

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产品操作手册

产品介绍

Tiamulin AI Summary

Tiamulin exhibits significant antibacterial activity against a broad spectrum of bacteria, including methicillin-sensitive and methicillin-resistant strains of Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, and Escherichia coli. The minimum inhibitory concentration (MIC) values vary widely depending on the bacterial strain and specific genetic mutations, with values ranging from as low as 0.06 ug/mL to greater than 128.0 ug/mL. The compound shows potent activity particularly against methicillin-resistant Staphylococcus aureus (MRSA) with MIC values from 0.5 to 1.0 ug/mL, and demonstrates bactericidal properties with minimum bactericidal concentration (MBC) values from 1.0 to 2.0 ug/mL. Tiamulin also binds to the 23S rRNA in Escherichia coli, with significant binding affinity evidenced by chemical footprinting analyses at binding sites U2506 and U2585. Additionally, it shows activity against bacterial strains with genetic resistance mechanisms, such as those harboring cfr, fexA, and multiple resistance genes, although its effectiveness is reduced in these cases with higher MIC values. In vivo studies highlight its efficacy in reducing bacterial loads and improving survival rates in mouse models of MRSA infection. Furthermore, the compound exhibits moderate to strong post-antibiotic effects and efficacy in systemic infection models. The compound also shows P-glycoprotein (P-gp) inhibitory activity, enhancing doxorubicin-induced antitumor effects in cell models. Overall, Tiamulin demonstrates promising antibacterial properties, particularly against resistant strains of Staphylococcus aureus and could be a potential candidate for further development as a therapeutic agent for bacterial infections..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Tiamulin (Thiamutilin) is a semisynthetic pleuromutilin antibiotic
别名	泰妙菌素, Thiamutilin

化学信息

分子量	493.74
分子式	C₂₈H₄₇NO₄S
CAS No.	55297-95-5
Smiles	[H][C@@]12C(=O)CC[C@]11CC[C@@H](C)[C@@]2(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]1C)OC(=O)CSCCN(CC)CC
密度	1.0160 g/cm3 (Estimated)
颜色	Transparent
物理性状	Oil

储存&溶解度

存储

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (506.34 mM), Sonication is recommended.

Ethanol: 2 mg/mL (4.05 mM), Sonication is recommended.

H2O: 11 mg/mL (22.28 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.13 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0254 mL	10.1268 mL	20.2536 mL	101.2679 mL

H2O/DMSO

	1mg	5mg	10mg	50mg
5 mM	0.4051 mL	2.0254 mL	4.0507 mL	20.2536 mL
10 mM	0.2025 mL	1.0127 mL	2.0254 mL	10.1268 mL
20 mM	0.1013 mL	0.5063 mL	1.0127 mL	5.0634 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0405 mL	0.2025 mL	0.4051 mL	2.0254 mL
100 mM	0.0203 mL	0.1013 mL	0.2025 mL	1.0127 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

veterinary Tiamulin swine pneumonia Inhibitor inhibit enzootic dysentery Bacterial Antibiotic

Tiamulin

Tiamulin

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产品介绍

计算器

体内实验配液计算器

剂量转换

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