SIB-1757 was given by either intrathecal (i.th.), subcutaneous (s.c.) or intraplantar (i.pl.) injection.?In SNL rats, i.th.?SIB-1757 produced a partial reversal of tactile allodynia with a shallow dose-response curve ranging over three-orders of magnitude;?SIB-1757 was inactive against allodynia when given systemically.?SIB-1757 produced full reversal of thermal hyperalgesia in SNL rats following administration either spinally or locally to the injured paw;?administration to the contralateral paw had no effect.?SIB-1757 did not produce antinociception in either the SNL or sham-operated rats by any route[1].