规格

价格

库存

数量

1 mg

¥ 497

现货

5 mg

¥ 1,230

现货

10 mg

¥ 1,990

现货

25 mg

¥ 3,890

现货

50 mg

¥ 5,550

现货

100 mg

¥ 7,550

现货

200 mg

¥ 9,870

现货

1 mL x 10 mM (in DMSO)

¥ 843

现货

生物活性

产品描述	Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase).Liarozole dihydrochloride is an imidazole derivative; it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders.
靶点活性	CYP26:7 μM (IC50)
体外活性	Liarozole 在牛肾上腺微粒体中抑制17α-羟化酶活性（IC50=0.15 μM）[1]。在人肝癌细胞中对胆固醇合成具有适度抑制作用（IC50=5 μM）[1]。同时，Liarozole 抑制仓鼠肝微粒体（IC50=2.2 μM）、大鼠肝同源物（IC50=0.14 μM）、Dunning 前列腺癌同源物（IC50=0.26 μM）以及MCF-7人乳腺癌细胞中维甲酸代谢成更极性代谢产物的过程（10μM时几乎完全阻断）[1]。
别名	利阿唑, R75251 dihydrochloride

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (178.13 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.48 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO