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Aminopeptidase-IN-1

Name: Aminopeptidase-IN-1
Brand: TargetMol
SKU: T61278
Price: 328 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 氨基肽酶-IN1

货号 T61278Cas号 374102-08-6 一键复制产品信息纯度: 98.34%

很棒

Aminopeptidase-IN-1 是一种有效的胰岛素调节氨肽酶 (IRAP) 抑制剂（Ki： 7.7 μM）。Aminopeptidase-IN-1 可用于认知和记忆障碍的研究。

Aminopeptidase-IN-1

一键复制产品信息

很棒

纯度: 98.34%

货号 T61278Cas号 374102-08-6

别名 氨基肽酶-IN1

Aminopeptidase-IN-1 是一种有效的胰岛素调节氨肽酶 (IRAP) 抑制剂（Ki： 7.7 μM）。Aminopeptidase-IN-1 可用于认知和记忆障碍的研究。

规格	价格	库存
5 mg	¥ 328	现货
10 mg	¥ 463	现货
25 mg	¥ 863	现货
50 mg	¥ 1,330	现货
100 mg	¥ 1,970	现货
500 mg	¥ 4,770	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 98.34%

颜色: 黄色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

Aminopeptidase-IN-1 AI Summary

Aminopeptidase-IN-1 shows bioactivity in various assays, including inhibiting Tau fibril formation by binding to tau fibrils in assays utilizing fluorescence polarization and Thioflavin T binding. It demonstrates cytotoxic effects on NIH3T3 cells as shown in the Luminescence Cell-Based Dose Response HTS assay and inhibits ROR gamma transcriptional activity. Additionally, Aminopeptidase-IN-1 inhibits enzymes such as aldehyde dehydrogenase 1, Sfp phosphopantetheinyl transferase, and JMJD2A-Tudor Domain, modulates lipid storage in Drosophila S3 cells, and inhibits Trypanosoma cruzi replication. It also acts on the ERK signaling pathway and histone lysine methyltransferase G9a, and serves as an antagonist for the Neuropeptide S receptor and BAZ2B. Moreover, it induces synthetic lethality in tumor cells producing 2HG in specific cell lines, inhibits MBNL1-poly(CUG) RNA binding, and induces DNA re-replication in normal breast cells. Aminopeptidase-IN-1 has antiviral activity against Foot and Mouth Disease Virus and inhibits IRAP in HEKT cells, with a Ki value of 7700 nM, as assessed by the hydrolysis of L-leucine-4-methyl-7-coumarinylamide after 30 minutes. These findings suggest that Aminopeptidase-IN-1 exhibits a diverse range of bioactivities, including anti-tau fibrillation, cytotoxicity, enzyme inhibition, and antiviral properties..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Aminopeptidase-IN-1 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) (Ki: 7.7 μM).Aminopeptidase-IN-1 can be used in studies of cognitive and memory disorders.
靶点活性	IRAP:7.7 μM(Ki)
别名	氨基肽酶-IN1

化学信息

分子量	356.33
分子式	C₁₈H₁₆N₂O₆
CAS No.	374102-08-6
Smiles	CCOC(=O)C1=C(N)Oc2cc(O)ccc2C1c1ccc(cc1)[N+]([O-])=O

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 60 mg/mL (168.38 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.61 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8064 mL	14.0319 mL	28.0639 mL	140.3194 mL
5 mM	0.5613 mL	2.8064 mL	5.6128 mL	28.0639 mL
10 mM	0.2806 mL	1.4032 mL	2.8064 mL	14.0319 mL
20 mM	0.1403 mL	0.7016 mL	1.4032 mL	7.0160 mL
50 mM	0.0561 mL	0.2806 mL	0.5613 mL	2.8064 mL
100 mM	0.0281 mL	0.1403 mL	0.2806 mL	1.4032 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。