规格

价格

库存

数量

1 mg

¥ 779

现货

5 mg

¥ 1,980

现货

10 mg

¥ 2,830

现货

25 mg

¥ 4,130

现货

50 mg

¥ 6,110

现货

100 mg

¥ 8,380

现货

500 mg

¥ 16,700

现货

生物活性

产品描述	BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.
体外活性	BSJ-03-123 快速引发与 CDK6 和 CRBN 形成剂量依赖的三元复合体，但与 CDK4 和 CRBN 无法形成此类复合体。通过用 palbo 或 lenalidomide 预处理阻断 CDK6 或 CRBN 的结合位点可阻止三元复合体的形成。
细胞实验	4x10^6 MV4-11 CRBN-/- cells were treated for 3 h with 20 μM palbociclib, BSJ-03-123 or vehicle. 1x10^6 cells were spun down at 500 x g for 5 min, and the supernatant removed. Pellets were incubated at 46, 49, 52 or 55°C for 3 min followed by 3 min incubation at room temperature. 30 μl of lysis buffer (20 mM Tris-HCl pH 8.0, 120 mM NaCl, 0.5% NP-40, protease inhibitors) were added and cells lysed by 3 rounds of snap freezing and thawing. Denatured proteins were removed by 20 min centrifugation at 14.000 x g at 4°C and supernatants analyzed by Western Blotting.

化学信息

分子量	937.01
分子式	C₄₇H₅₆N₁₀O₁₁
CAS No.	2361493-16-3
Smiles	O=C1N(C=2C(C(C)=C1C(C)=O)=CN=C(NC3=CC=C(C=N3)N4CCN(CCOCCOCCOCCNC(COC5=C6C(C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=CC=C5)=O)CC4)N2)C8CCCC8

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 115 mg/mL (122.73 mM), Sonication is recommended.

H2O: Insoluble

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (4.27 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0672 mL	5.3361 mL	10.6722 mL	53.3612 mL
5 mM	0.2134 mL	1.0672 mL	2.1344 mL	10.6722 mL
10 mM	0.1067 mL	0.5336 mL	1.0672 mL	5.3361 mL
20 mM	0.0534 mL	0.2668 mL	0.5336 mL	2.6681 mL
50 mM	0.0213 mL	0.1067 mL	0.2134 mL	1.0672 mL
100 mM	0.0107 mL	0.0534 mL	0.1067 mL	0.5336 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

BSJ-03-123

BSJ-03-123

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词

BSJ-03-123

BSJ-03-123

BSJ-03-123 相关产品

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词