Penicillamine

Name: Penicillamine
Brand: TargetMol
SKU: T0983
Price: 145 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.8%

货号 T0983Cas号 52-67-5

别名 青霉胺, D-penicillamine, Dimethyl Cysteine, D-(-)-Penicillamine, Artamine

Penicillamine (Artamine) 是一种 penicillin 的代谢降解产物，是一种螯合剂，可作用于威尔逊氏病。

Penicillamine

一键复制产品信息

很棒

纯度: 99.8%

货号 T0983 别名 青霉胺, D-penicillamine, Dimethyl Cysteine, D-(-)-Penicillamine, ArtamineCas号 52-67-5

Penicillamine (Artamine) 是一种 penicillin 的代谢降解产物，是一种螯合剂，可作用于威尔逊氏病。

规格	价格	库存
10 mg	¥ 145	现货
25 mg	¥ 212	现货
50 mg	¥ 293	现货
100 mg	¥ 415	现货
500 mg	¥ 986	现货
1 g	¥ 1,450	现货

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纯度: 99.69%

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产品介绍

Penicillamine AI Summary

Penicillamine exhibits a broad spectrum of bioactivities with an emphasis on anti-inflammatory, antioxidant, inhibitory, and antiviral properties. Notable anti-inflammatory effects include inhibition of collagen II-induced arthritis in rats, reduction in paw edema, and decreased immune response to collagen II antigen. It also shows significant singlet oxygen and peroxynitrite scavenging activities with respective IC50 values of 4900.0 nM and 5.13 uM, indicating potent antioxidant properties. In terms of inhibitory activities, Penicillamine inhibits TNF-alpha production, zinc chelation, and cystathionine gamma-lyase with IC50 values indicating variable levels of potency. The compound also manifests considerable inhibitory effects on human liver enzyme activation, sodium fluorescein uptake in OATP1B1 and OATP1B3 transfected cells, and human HDAC6 enzyme, making it a significant multi-target inhibitor. The antiviral capacity of Penicillamine against SARS-CoV-2 is demonstrated by its inhibitory effects on virus-induced cytotoxicity in Caco-2 and VERO-6 cells, although at a moderate potency with IC50 values greater than 20,000.0 nM. Despite its therapeutic potential, Penicillamine has shown moderate liver toxicity and has been identified to cause hepatotoxic effects in clinical trials, suggesting caution in its application. The compound's diverse bioactivities and potential therapeutic applications warrant further investigation for optimizing its efficacy and safety profiles..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Penicillamine (Artamine), possessing antineoplastic properties, induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Artamine is a beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, Artamine chelates with heavy metals and increases their urinary excretion.
别名	青霉胺, D-penicillamine, Dimethyl Cysteine, D-(-)-Penicillamine, Artamine

化学信息

分子量	149.21
分子式	C₅H₁₁NO₂S
CAS No.	52-67-5
Smiles	CC(C)(S)[C@@H](N)C(O)=O
密度	1.204g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 1 mg/mL (6.7 mM), Sonication is recommended.

H2O: 71.43 mg/mL (478.72 mM), Sonication is recommended.

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	6.7020 mL	33.5098 mL	67.0196 mL	335.0982 mL
5 mM	1.3404 mL	6.7020 mL	13.4039 mL	67.0196 mL

H2O

	1mg	5mg	10mg	50mg
10 mM	0.6702 mL	3.3510 mL	6.7020 mL	33.5098 mL
20 mM	0.3351 mL	1.6755 mL	3.3510 mL	16.7549 mL
50 mM	0.1340 mL	0.6702 mL	1.3404 mL	6.7020 mL
100 mM	0.0670 mL	0.3351 mL	0.6702 mL	3.3510 mL