ML-184

Name: ML-184
Brand: TargetMol
SKU: T8571
Price: 745 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.45%

货号 T8571Cas号 794572-10-4

别名 CID2440433

ML-184 (CID2440433) 是一种选择性的GPR55激动剂(EC50: 250 nM)，对 GPR55 的选择性比 GPR35、CB1 和 CB2 的高100 倍以上。它可以激活 GPR55 ，诱导 ERK1/2 磷酸化并促使PKCβII 向质膜移位。它能在体外诱导神经干细胞增殖，并加速进神经元分化。

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ML-184

一键复制产品信息

很棒

纯度: 99.45%

货号 T8571 别名 CID2440433Cas号 794572-10-4

规格	价格	库存
1 mg	¥ 745	现货
5 mg	¥ 1,380	现货
10 mg	¥ 2,230	现货
25 mg	¥ 3,790	现货
50 mg	¥ 5,430	现货
100 mg	¥ 7,390	现货
200 mg	¥ 9,870	现货
1 mL x 10 mM (in DMSO)	¥ 1,450	现货

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纯度: 99.45%

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产品介绍

ML-184 AI Summary

ML-184 exhibits a variety of bioactivities relevant to several therapeutic pathways. It is an inhibitor of Aldehyde Dehydrogenase 1 (ALDH1A1) with a potency of 35481.3 nM and targets the Menin-MLL Interaction in MLL-related leukemias with a potency of 2511.9 nM. Additionally, it inhibits the JMJD2A-Tudor Domain with a potency of 50118.7 nM and human tyrosyl-DNA phosphodiesterase 1 (TDP1) with potencies of 23109.3 nM in the absence of CPT and 29092.9 nM in the presence of CPT. The compound also acts as an antagonist of the etiologic mutation gsp responsible for Fibrous Dysplasia/McCune-Albright Syndrome with a potency of 12589.3 nM. Notably, ML-184 functions as a selective agonist of GPR55, with an EC50 of 263.0 nM, and increases GFP-tagged beta arrestin2 recruitment in human U2OS cells, with an EC50 of 260.0 nM. However, it has no significant agonist activity at the human brain CB1 and CB2 receptors, with EC50 values exceeding 30000.0 nM for both assays. These activities suggest diverse therapeutic potential for ML-184..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	ML-184 (CID2440433) is a potent synthetic agonist of GPR55 with EC50 of 0.26 μM.
别名	CID2440433

化学信息

分子量	470.63
分子式	C₂₅H₃₄N₄O₃S
CAS No.	794572-10-4
Smiles	CN(C)S(=O)(=O)c1ccc(N2CCCC2)c(c1)C(=O)N1CCN(CC1)c1cccc(C)c1C
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 10 mg/mL (21.25 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1248 mL	10.6241 mL	21.2481 mL	106.2406 mL
5 mM	0.4250 mL	2.1248 mL	4.2496 mL	21.2481 mL
10 mM	0.2125 mL	1.0624 mL	2.1248 mL	10.6241 mL
20 mM	0.1062 mL	0.5312 mL	1.0624 mL	5.3120 mL