Ofloxacin

Name: Ofloxacin
Brand: TargetMol
SKU: T0902
Price: 137 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.87%

货号 T0902Cas号 82419-36-1

别名 氧氟沙星, 菲宁达, Tarivid, Oxaldin, Hoe-280, Floxin, DL8280

Ofloxacin (Oxaldin) 是可抑制细菌DNA 旋转酶的一种氟喹诺酮类抗生素。

Ofloxacin

一键复制产品信息

很棒

纯度: 99.87%

货号 T0902 别名 氧氟沙星, 菲宁达, Tarivid, Oxaldin, Hoe-280, Floxin, DL8280Cas号 82419-36-1

Ofloxacin (Oxaldin) 是可抑制细菌DNA 旋转酶的一种氟喹诺酮类抗生素。

规格	价格	库存
100 mg	¥ 137	现货
500 mg	¥ 291	现货
1 g	¥ 375	现货
5 g	¥ 832	现货

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产品介绍

Ofloxacin AI Summary

**Ofloxacin** exhibits significant broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria. It displays low Minimum Inhibitory Concentration (MIC) values, ranging from 0.1 to 3.13 ug/mL, against various bacteria such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Enterococcus faecalis. Noteworthy, it is effective even against methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Mycobacterium tuberculosis strains. In addition to its antibacterial properties, Ofloxacin inhibits DNA gyrase in Escherichia coli, with an IC50 value of 1.0 ug/mL, and successfully disrupts DNA replication. The compound demonstrates strong in vivo efficacy in treating systemic infections in mice, displaying effective doses (ED50) of 2.0 mg/kg administered orally and as low as 0.8 mg/kg administered subcutaneously against E. coli infections. Furthermore, Ofloxacin shows favorable pharmacokinetic properties, including high bioavailability, reasonable permeability across the blood-brain barrier, and low cytotoxicity towards mammalian cells (IC50 > 500.0 ug/mL). This highlights its potential in addressing bacterial infections, especially those resistant to conventional antibiotics..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Ofloxacin (Oxaldin) is a fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzymes involved in DNA replication and repair, resulting in cell death in sensitive bacterial species.
别名	氧氟沙星, 菲宁达, Tarivid, Oxaldin, Hoe-280, Floxin, DL8280

化学信息

分子量	361.37
分子式	C₁₈H₂₀FN₃O₄
CAS No.	82419-36-1
Smiles	O=C1C=2C3=C(C(=C(F)C2)N4CCN(C)CC4)OCC(C)N3C=C1C(O)=O
密度	1.2688 g/cm3 (Estimated)

储存&溶解度

存储

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 3.62 mg/mL (10.02 mM), Sonication is recommended.