Name: IACS-9571
Brand: TargetMol
SKU: T11597
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 69,500

6-8周

50 mg

待询

6-8周

100 mg

待询

6-8周

生物活性

产品描述	IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).
靶点活性	BRPF1:14 nM , TRIM24:(kd)31 nM , TRIM24:8 nM
体外活性	IACS-9571 is a selective dual TRIM24/BRPF1 inhibitor (Kd = 1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 does not interact with the BET sub-family of bromodomains, displaying greater than 7,700-fold selectivity versus BRD4(1, 2) relative to TRIM24.IACS-9571 shows excellent cellular potency with EC50 of 50 nM.?IACS-9571 (1 μM) has potent activities against a panel of 32 bromodomains.
别名	ASIS-P040

化学信息

分子量	642.76
分子式	C₃₂H₄₂N₄O₈S
CAS No.	1800477-30-8
Smiles	CN1C=2C(=CC(NS(=O)(=O)C3=CC(OC)=C(OC)C=C3)=C(OC4=CC(OCCCCN(C)C)=CC(OCCC)=C4)C2)N(C)C1=O
密度	1.246 g/cm3 (Predicted)