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Cinobufagin

Name: Cinobufagin
Brand: TargetMol
SKU: T3432
Price: 282 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.97%

货号 T3432Cas号 470-37-1

别名 华蟾酥毒基, 华蟾蜍精, Cinobufagine

Cinobufagin (Cinobufagine) 是一种具有抗肿瘤功效的天然产物。

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Cinobufagin

一键复制产品信息

很棒

纯度: 99.97%

货号 T3432 别名 华蟾酥毒基, 华蟾蜍精, CinobufagineCas号 470-37-1

Cinobufagin (Cinobufagine) 是一种具有抗肿瘤功效的天然产物。

规格	价格	库存
1 mg	¥ 282	现货
5 mg	¥ 943	现货
10 mg	¥ 1,400	现货
25 mg	¥ 2,160	现货
50 mg	¥ 2,990	现货
100 mg	¥ 4,630	现货
200 mg	¥ 6,430	现货
1 mL x 10 mM (in DMSO)	¥ 967	现货

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纯度: 99.97%

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COA HNMR LCMS 产品操作手册

产品介绍

Cinobufagin AI Summary

Cinobufagin exhibits a varying degree of binding affinity against different human monoclonal antibodies, with the strongest binding observed for mAb-11E6 and mAb-5C2, as indicated by their IC50 ratios of 800.0 and 570.0, respectively. It shows weaker binding for mAb-7F2 and mAb-1B3, with IC50 ratios of 1700.0 and 98000.0, respectively. Additionally, Cinobufagin displays significant anticancer properties, showing inhibitory activity against various cell lines including PLC/PRF/5 liver carcinoma cells, HepG2, HeLa, BGC823, and Bel7402 cells with notable IC50 values. It also demonstrates strong cytotoxicity against human HL60 cells (IC50 <0.01 µg/mL) and human KB cells (IC50 = 0.21 µg/mL). Furthermore, it inhibits ELG1-dependent DNA repair with potencies ranging from 44.5 nM to 250.4 nM and inhibits Lassa and Marburg virus binding or entry into cells with potencies of 199.5 nM and 89.1 nM, respectively. Despite showing moderate inhibition against electric eel AChE and horse BChE, Cinobufagin does not exhibit significant cytotoxicity against mouse MH60 cells. Lastly, it demonstrates drug metabolism activity in various liver microsomes and recombinant CYP3A4 enzymes, indicating potential species-specific metabolism patterns..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Cinobufagin (Cinobufagine) is a selective Na+/K+-ATPase inhibitor. The activity of Cinobufagin is same as ouabain.
别名	华蟾酥毒基, 华蟾蜍精, Cinobufagine

化学信息

分子量	442.54
分子式	C₂₆H₃₄O₆
CAS No.	470-37-1
Smiles	CC(=O)[C@H]1[C@H]2O[C@]22[C@@H]3CC[C@@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]2(C)[C@H]1c1ccc(=O)oc1
密度	1.261 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 132.5 mg/mL (299.41 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.52 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2597 mL	11.2984 mL	22.5968 mL	112.9841 mL
5 mM	0.4519 mL	2.2597 mL	4.5194 mL	22.5968 mL
10 mM	0.2260 mL	1.1298 mL	2.2597 mL	11.2984 mL
20 mM	0.1130 mL	0.5649 mL	1.1298 mL	5.6492 mL
50 mM	0.0452 mL	0.2260 mL	0.4519 mL	2.2597 mL
100 mM	0.0226 mL	0.1130 mL	0.2260 mL	1.1298 mL