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Anti-Antithrombin III Antibody (1P791)
还可以产品编号 TMAY-00337
Anti-Antithrombin III Antibody (1P791) 是一种 Rabbit 抗体，靶向 Antithrombin III。Anti-Antithrombin III Antibody (1P791) 可用于 ELISA。
Anti-Antithrombin III Antibody (1P791)
Anti-Antithrombin III Antibody (1P791)
还可以产品编号 TMAY-00337
Anti-Antithrombin III Antibody (1P791) 是一种 Rabbit 抗体，靶向 Antithrombin III。Anti-Antithrombin III Antibody (1P791) 可用于 ELISA。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Antithrombin III Antibody (1P791) is a Rabbit antibody targeting Antithrombin III. Anti-Antithrombin III Antibody (1P791) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 1P791 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human Antithrombin III / ATIII / SerpinC1 (rh Antithrombin III / ATIII / SerpinC1; TMPY-00916; NP_000479.1; Met 1-Lys 464). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prognostic significance in septic patients. SerpinC1 synthesized in the liver is the principal plasma serpin of blood coagulation proteases and inhibits thrombin and other factors such as Xa by the formation of covalently linked complexes. Thus it is one of the most important coagulation inhibitors and the fundamental enzyme for the therapeutical action of heparin. In common with SerpinA5 and D1, the inhibitory activity of SerpinC1 undergoes a dramatic increase in the presence of heparin and other glycosaminoglycans. ATIII mediates the promotion of prostaglandin release, an inhibitor of leucocyte activation and downregulator of many proinflammatory cytokines. Antithrombin III exerts anti-inflammatory properties in addition to its anti-coagulative mechanisms. In animal models of sepsis, ATIII affected cytokine plasma concentrations with a decrease of pro-inflammatory cytokines. The deficiency or functional abnormality of ATIII may result in an increased risk of thromboembolic disease, such as deep vein thrombosis and pulmonary embolism. In addition, it has been reported that SerpinC1 can alter or influence inflammatory processes via inhibition of NF-κB activation or actin polymerization. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human Serpin C1 protein (TMPY-00916) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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