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Anti-Antithrombin III Antibody (1P791)

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Anti-Antithrombin III Antibody (1P791)
产品编号 TMAY-00337
别名 SerpinC1, serpin peptidase inhibitor, clade C (antithrombin), member 1

Anti-Antithrombin III Antibody (1P791) 是一种 Rabbit 抗体，靶向 Antithrombin III。Anti-Antithrombin III Antibody (1P791) 可用于 ELISA。

Anti-Antithrombin III Antibody (1P791)
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Anti-Antithrombin III Antibody (1P791)

Rating icon 还可以
Anti-Antithrombin III Antibody (1P791)
产品编号 TMAY-00337 别名 SerpinC1, serpin peptidase inhibitor, clade C (antithrombin), member 1

Anti-Antithrombin III Antibody (1P791) 是一种 Rabbit 抗体，靶向 Antithrombin III。Anti-Antithrombin III Antibody (1P791) 可用于 ELISA。

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100 μL
¥ 2,294
5日内发货
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产品介绍

生物活性
产品描述
Anti-Antithrombin III Antibody (1P791) is a Rabbit antibody targeting Antithrombin III. Anti-Antithrombin III Antibody (1P791) can be used in ELISA.
别名SerpinC1, serpin peptidase inhibitor, clade C (antithrombin), member 1
Ig Type
Rabbit IgG
克隆号
1P791
交叉反应
Human
应用
ELISA
推荐剂量
ELISA: 1:5000-1:10000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human Antithrombin III / ATIII / SerpinC1 (rh Antithrombin III / ATIII / SerpinC1; TMPY-00916; NP_000479.1; Met 1-Lys 464).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prognostic significance in septic patients. SerpinC1 synthesized in the liver is the principal plasma serpin of blood coagulation proteases and inhibits thrombin and other factors such as Xa by the formation of covalently linked complexes. Thus it is one of the most important coagulation inhibitors and the fundamental enzyme for the therapeutical action of heparin. In common with SerpinA5 and D1, the inhibitory activity of SerpinC1 undergoes a dramatic increase in the presence of heparin and other glycosaminoglycans. ATIII mediates the promotion of prostaglandin release, an inhibitor of leucocyte activation and downregulator of many proinflammatory cytokines. Antithrombin III exerts anti-inflammatory properties in addition to its anti-coagulative mechanisms. In animal models of sepsis, ATIII affected cytokine plasma concentrations with a decrease of pro-inflammatory cytokines. The deficiency or functional abnormality of ATIII may result in an increased risk of thromboembolic disease, such as deep vein thrombosis and pulmonary embolism. In addition, it has been reported that SerpinC1 can alter or influence inflammatory processes via inhibition of NF-κB activation or actin polymerization.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human Serpin C1 protein (TMPY-00916)
抗原种属
Human
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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