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TMPyP4 tosylate

Name: TMPyP4 tosylate
Brand: TargetMol
SKU: T13174
Price: 108 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.85%

货号 T13174Cas号 36951-72-1

别名 TMP 1363

TMPyP4 tosylate (TMP 1363) 是四链体 (G-quadruplex) 的特异性配体，抑制四链体和 IGF-1 之间的相互作用。它也是端粒酶抑制剂，在骨肉瘤细胞系中显示抗肿瘤作用。

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TMPyP4 tosylate

一键复制产品信息

很棒

纯度: 99.85%

货号 T13174 别名 TMP 1363Cas号 36951-72-1

规格	价格	库存
2 mg	¥ 108	现货
5 mg	¥ 148	现货
10 mg	¥ 198	现货
25 mg	¥ 372	现货
50 mg	¥ 619	现货
100 mg	¥ 877	现货
200 mg	¥ 1,290	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.85%

颜色: 紫色

性状: Solid

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资源下载:

COA HNMR HPLC 产品操作手册

产品介绍

TMPyP4 tosylate AI Summary

TMPyP4 tosylate is a multi-faceted bioactive compound with significant inhibitory effects across various biological activities and targets. It inhibits PrP-res formation in mouse ScN2a cells and prion Fukuoka1 strain infected mouse N2a#58 cells with IC50 values of 130.0 nM and 160.0 nM, respectively. The compound also demonstrates potent telomerase inhibition across multiple assays against Thermus aquaticus DNA polymerase, tetrahymena telomerase, and human HeLa cells, with IC50 values ranging from 60.0 nM to 150.0 nM, and achieves maximum inhibition in some cases. TMPyP4 tosylate binds to HIV 1 HXB2 G-quadruplex LTR DNA sequences, stabilizing these structures as indicated by increases in melting temperature (Delta Tm) in the presence of K+. It also exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus and Burkholderia cepacia, particularly under specific irradiation conditions. The compound binds and inhibits human ACC1 promoter G-quadruplex DNA, showing significant binding affinities and inhibition of ACC1 gene expression in human HeLa cells. It also demonstrates antiproliferative activity against various cancer cell lines including MDA-MB-231, PC3, OVCAR3, bone marrow cells, and MCR5A, with GI50 values ranging around 14,000 to 16,800 nM, and telomerase inhibition in MDA-MB-231 cells ranging from 60.0% to 80.0%. TMPyP4 tosylate has antileishmanial activity against Leishmania major promastigotes (IC50 = 20820.0 nM), but displays lesser potency against Trypanosoma brucei brucei and Plasmodium falciparum, and shows cytotoxicity against human MRC5 cells at high concentrations. It strongly binds and stabilizes various G-quadruplex DNA structures and demonstrates photodynamic antibacterial activity against Pseudomonas aeruginosa, as well as photodynamic cytotoxicity against human A549 cells with significant light-mediated cell growth inhibition (IC50 = 300.0 nM). This extensive profile positions TMPyP4 tosylate as a valuable agent for potential therapeutic applications in prion diseases, telomerase-related conditions, bacterial infections, cancer, and diseases associated with G-quadruplex DNA targets..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.
别名	TMP 1363

化学信息

分子量	1363.6
分子式	C₇₂H₆₆N₈O₁₂S₄
CAS No.	36951-72-1
Smiles	Cc1ccc(cc1)S(O)(=O)=O.Cc1ccc(cc1)S(O)(=O)=O.Cc1ccc(cc1)S(O)(=O)=O.Cc1ccc(cc1)S(O)(=O)=O.CN1CC=C(C=C1)c1c2ccc(n2)c(C2=CCN(C)C=C2)c2ccc([nH]2)c(C2=CCN(C)C=C2)c2ccc(n2)c(C2=CCN(C)C=C2)c2ccc1[nH]2
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 6.2 mg/mL (4.55 mM), Sonication is recommended.

DMSO: 18.33 mg/mL (13.44 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (0.73 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.7334 mL	3.6668 mL	7.3335 mL	36.6676 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.1467 mL	0.7334 mL	1.4667 mL	7.3335 mL
10 mM	0.0733 mL	0.3667 mL	0.7334 mL	3.6668 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。