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Meticrane

Name: Meticrane
Brand: TargetMol
SKU: T0275
Price: 150 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 蒲硫杂茶磺胺, 美替克仑, Fontiliz, Arresten

货号 T0275Cas号 1084-65-7 一键复制产品信息纯度: 99.16%

很棒

Meticrane (Arresten) 是一种磺胺类衍生物，具有类似噻嗪类利尿剂的活性，可于研究原发性高血压。

Meticrane

一键复制产品信息

很棒

纯度: 99.16%

货号 T0275Cas号 1084-65-7

别名 蒲硫杂茶磺胺, 美替克仑, Fontiliz, Arresten

Meticrane (Arresten) 是一种磺胺类衍生物，具有类似噻嗪类利尿剂的活性，可于研究原发性高血压。

规格	价格	库存
50 mg	¥ 289	现货
100 mg	¥ 413	现货
200 mg	¥ 588	现货
500 mg	¥ 980	现货
1 mL x 10 mM (in DMSO)	¥ 150	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.16%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

Meticrane AI Summary

Meticrane exhibits a range of bioactivities including moderate potency in modulating Lamin A splicing (707.9 nM) and relatively high potency as an inhibitor or substrate of Cytochrome P450 2C9 (12589.3 nM). It has weaker potency in inhibiting HP1-beta Chromodomain interactions with methylated histone tails (100000.0 nM) and demonstrates moderate potency in the Schwann cell PMP22 intronic element luciferase assay (3886.4 nM). It induces DNA re-replication in normal breast cells (20596.2 nM) and acts as an antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2) with a potency of 63095.7 nM. The compound also shows activity in blocking Ebola virus entry with AC50 values ranging from 3.162 to 5011.9 uM in different assays. Regarding antiviral activity, Meticrane was tested against SARS-CoV-2 in various assays. It shows inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 uM after 48 hours (-7.21%) and in VERO-6 cells at 10 uM concentration, with an IC50 value greater than 20000.0 nM. It also demonstrated a hit score of 0.2902 in HRCE cells against the SARS-CoV-2 (USA-WA1/2020 strain). However, in Vero E6 cells, it did not exhibit inhibitory activity against SARS-CoV-2 (negative inhibition index of -0.03039). Additionally, it inhibits the SARS-CoV-2 3CL-Pro protease by 13.35% at 20µM using a FRET-based assay. Furthermore, Meticrane shows inhibitory activity on human HDAC6 with inhibition percentages of 7.25% using a commercial peptide substrate and -7.26% with a custom peptide substrate, suggesting a possible differential effect based on substrate type. Despite these activities, the compound demonstrated limited bioactivity against a broad spectrum of targets, including dopamine and adrenergic receptors, among others, with no significant binding affinities or inhibitory effects observed. Overall, Meticrane has a diverse bioactivity profile but shows limited strong bioactivity against the broad range of tested targets..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.
别名	蒲硫杂茶磺胺, 美替克仑, Fontiliz, Arresten

化学信息

分子量	275.34
分子式	C₁₀H₁₃NO₄S₂
CAS No.	1084-65-7
Smiles	Cc1cc2CCCS(=O)(=O)c2cc1S(N)(=O)=O
密度	1.464g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 60 mg/mL (217.91 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.26 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6319 mL	18.1594 mL	36.3187 mL	181.5937 mL
5 mM	0.7264 mL	3.6319 mL	7.2637 mL	36.3187 mL
10 mM	0.3632 mL	1.8159 mL	3.6319 mL	18.1594 mL
20 mM	0.1816 mL	0.9080 mL	1.8159 mL	9.0797 mL
50 mM	0.0726 mL	0.3632 mL	0.7264 mL	3.6319 mL
100 mM	0.0363 mL	0.1816 mL	0.3632 mL	1.8159 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。