Amitraz

Name: Amitraz
Brand: TargetMol
SKU: T1632
Price: 147 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.88%

货号 T1632Cas号 33089-61-1

别名 双甲脒, NSC 324552, BTS-27419

Amitraz (NSC 324552) 是一种非系统性杀螨剂和杀虫剂,，可治疗犬蠕形螨。它具有α-肾上腺素能激动剂活性, 与中枢神经系统的章鱼胺受体相互作用, 抑制单胺氧化酶和前列腺素合成。

Amitraz

一键复制产品信息

很棒

纯度: 99.88%

货号 T1632 别名 双甲脒, NSC 324552, BTS-27419Cas号 33089-61-1

规格	价格	库存
200 mg	¥ 147	现货
500 mg	¥ 248	现货
1 g	¥ 357	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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COA LCMS HNMR 产品操作手册

产品介绍

Amitraz AI Summary

Amitraz exhibits a wide range of bioactivities across various biological targets and systems. It shows high potency in modulating Lamin A splicing with an EC50 of 0.9 nM, while demonstrating significantly lower potency in other assays such as activating Cytochrome P450 3A4 (39810.7 nM) and thyroid hormone receptor beta (44668.4 nM). The compound functions as both an agonist and antagonist of peroxisome proliferator-activated receptor gamma (PPARγ) with potencies of 39810.7 nM and 50118.7 nM, respectively, and similarly activates Aryl hydrocarbon Receptor (50118.7 nM) and the antioxidant response element (ARE) signaling pathway (24336.5 nM). It induces DNA re-replication in SW480 colon adenocarcinoma cells with a potency of 33498.3 nM and exhibits modest inhibition of Human Apurinic/apyrimidinic Endonuclease 1 (APE1) at 31622.8 nM. In virological assays, it inhibits Ebola virus entry (25118.9 to 631.0 nM) and SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells. In addition to its antiviral capabilities, Amitraz demonstrates antitrypanosomal activity against Trypanosoma cruzi with an EC50 of 16000.0 nM and exhibits cytotoxicity against BESM cells with an EC50 of 33000.0 nM. It acts as a ligand for Alpha-2A adrenergic receptor and Imidazoline I2, Central receptors, showing IC50 values between 47.7 and 926.9 nM. The compound also demonstrates significant insecticidal activity against two-spotted spider mite Tetranychus urticae and shows toxicity to worker Bombus terrestris (bumblebees). Pharmacokinetically, Amitraz influences multiple physiological systems, including liver and kidney function, electrolyte balance, cholesterol metabolism, and various hematological parameters based on DrugMatrix assay results. Furthermore, it inhibits human HDAC6 enzyme activity, suggesting potential bioactivity in modulating epigenetic functions. Overall, Amitraz is a multifunctional molecule with broad-spectrum bioactivities, significant antiviral potential, insecticidal properties, and the ability to modulate multiple physiological and enzymatic pathways..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Amitraz (NSC 324552) is a white monoclinic crystals. Melting point 187-189°F (86-87°C). Insoluble in water. Used as an acaricide, insecticide and treatment of demodectic mange in dogs.
别名	双甲脒, NSC 324552, BTS-27419

化学信息

分子量	293.41
分子式	C₁₉H₂₃N₃
CAS No.	33089-61-1
Smiles	N(=CN(C=NC1=C(C)C=C(C)C=C1)C)C2=C(C)C=C(C)C=C2
密度	1.1280 g/cm3

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (170.41 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.82 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4082 mL	17.0410 mL	34.0820 mL	170.4100 mL
5 mM	0.6816 mL	3.4082 mL	6.8164 mL	34.0820 mL
10 mM	0.3408 mL	1.7041 mL	3.4082 mL	17.0410 mL
20 mM	0.1704 mL	0.8521 mL	1.7041 mL	8.5205 mL
50 mM	0.0682 mL	0.3408 mL	0.6816 mL	3.4082 mL
100 mM	0.0341 mL	0.1704 mL	0.3408 mL	1.7041 mL