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Amitraz

Name: Amitraz
Brand: TargetMol
SKU: T1632
Price: 147 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 双甲脒, NSC 324552, BTS-27419

货号 T1632Cas号 33089-61-1 一键复制产品信息纯度: 99.88%

很棒

Amitraz (NSC 324552) 是一种非系统性杀螨剂和杀虫剂,，可治疗犬蠕形螨。它具有α-肾上腺素能激动剂活性, 与中枢神经系统的章鱼胺受体相互作用, 抑制单胺氧化酶和前列腺素合成。

Amitraz

一键复制产品信息

很棒

纯度: 99.88%

货号 T1632Cas号 33089-61-1

别名 双甲脒, NSC 324552, BTS-27419

规格	价格	库存
200 mg	¥ 147	现货
500 mg	¥ 248	现货
1 g	¥ 357	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.88%

颜色: 黄色

资源下载: COA LCMS HNMR产品操作手册

产品介绍

Amitraz AI Summary

Amitraz exhibits a wide range of bioactivities across various biological targets and systems. It shows high potency in modulating Lamin A splicing with an EC50 of 0.9 nM, while demonstrating significantly lower potency in other assays such as activating Cytochrome P450 3A4 (39810.7 nM) and thyroid hormone receptor beta (44668.4 nM). The compound functions as both an agonist and antagonist of peroxisome proliferator-activated receptor gamma (PPARγ) with potencies of 39810.7 nM and 50118.7 nM, respectively, and similarly activates Aryl hydrocarbon Receptor (50118.7 nM) and the antioxidant response element (ARE) signaling pathway (24336.5 nM). It induces DNA re-replication in SW480 colon adenocarcinoma cells with a potency of 33498.3 nM and exhibits modest inhibition of Human Apurinic/apyrimidinic Endonuclease 1 (APE1) at 31622.8 nM. In virological assays, it inhibits Ebola virus entry (25118.9 to 631.0 nM) and SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells. In addition to its antiviral capabilities, Amitraz demonstrates antitrypanosomal activity against Trypanosoma cruzi with an EC50 of 16000.0 nM and exhibits cytotoxicity against BESM cells with an EC50 of 33000.0 nM. It acts as a ligand for Alpha-2A adrenergic receptor and Imidazoline I2, Central receptors, showing IC50 values between 47.7 and 926.9 nM. The compound also demonstrates significant insecticidal activity against two-spotted spider mite Tetranychus urticae and shows toxicity to worker Bombus terrestris (bumblebees). Pharmacokinetically, Amitraz influences multiple physiological systems, including liver and kidney function, electrolyte balance, cholesterol metabolism, and various hematological parameters based on DrugMatrix assay results. Furthermore, it inhibits human HDAC6 enzyme activity, suggesting potential bioactivity in modulating epigenetic functions. Overall, Amitraz is a multifunctional molecule with broad-spectrum bioactivities, significant antiviral potential, insecticidal properties, and the ability to modulate multiple physiological and enzymatic pathways..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Amitraz (NSC 324552) is a white monoclinic crystals. Melting point 187-189°F (86-87°C). Insoluble in water. Used as an acaricide, insecticide and treatment of demodectic mange in dogs.
别名	双甲脒, NSC 324552, BTS-27419

化学信息

分子量	293.41
分子式	C₁₉H₂₃N₃
CAS No.	33089-61-1
Smiles	N(=CN(C=NC1=C(C)C=C(C)C=C1)C)C2=C(C)C=C(C)C=C2
密度	1.1280 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 50 mg/mL (170.41 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.82 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4082 mL	17.0410 mL	34.0820 mL	170.4100 mL
5 mM	0.6816 mL	3.4082 mL	6.8164 mL	34.0820 mL
10 mM	0.3408 mL	1.7041 mL	3.4082 mL	17.0410 mL
20 mM	0.1704 mL	0.8521 mL	1.7041 mL	8.5205 mL
50 mM	0.0682 mL	0.3408 mL	0.6816 mL	3.4082 mL
100 mM	0.0341 mL	0.1704 mL	0.3408 mL	1.7041 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

α-adrenergic receptor Parasite NSC-324552 NSC324552 MonoamineOxidase Monoamine Oxidase MAO Inhibitor inhibit BTS27419 BTS 27419 Beta Receptor Amitraz AdrenergicReceptor Adrenergic Receptor

Amitraz

Amitraz

Amitraz 相关产品

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

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