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Acetohydroxamic acid

Name: Acetohydroxamic acid
Brand: TargetMol
SKU: T1592
Price: 120 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 乙酰氧肟酸, oxime, N-Hydroxyacetamide, Methylhydroxamic acid, Lithostat, AHA, Acetic acid

货号 T1592Cas号 546-88-3 一键复制产品信息纯度: 99.91%

很棒

Acetohydroxamic acid (N-Hydroxyacetamide) 是一种不可逆的细菌和植物尿素酶抑制剂，可研究慢性尿路感染。

Acetohydroxamic acid

一键复制产品信息

很棒

纯度: 99.91%

货号 T1592Cas号 546-88-3

别名 乙酰氧肟酸, oxime, N-Hydroxyacetamide, Methylhydroxamic acid, Lithostat, AHA, Acetic acid

Acetohydroxamic acid (N-Hydroxyacetamide) 是一种不可逆的细菌和植物尿素酶抑制剂，可研究慢性尿路感染。

规格	价格	库存
50 mg	¥ 120	现货
100 mg	¥ 223	现货
500 mg	¥ 488	现货
1 g	¥ 718	现货
1 mL x 10 mM (in DMSO)	¥ 235	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.91%

颜色: 白色

性状: Solid

资源下载: COA HPLC HNMR 产品操作手册

产品介绍

Acetohydroxamic acid AI Summary

Acetohydroxamic acid exhibits a broad spectrum of bioactivities and inhibitory effects across various biochemical targets. Its notable activities include: 1. **Enzyme Inhibition**: - **Carbonic Anhydrase II**: Inhibits human CA2 enzyme with an IC50 of 47,000 nM. - **Helicobacter pylori Urease**: Demonstrates notable inhibition with IC50 values ranging from 17,000 nM to 184,000 nM in various assays. - **Klebsiella aerogenes Urease**: Exhibits a Ki value of 2,600 nM. - **Jack Bean Urease**: Shows an IC50 of 41,500 nM. - **SARS-CoV-2 3CL-Pro Protease**: Inhibits with a 22.1% effect at 20 µM. - **Matrix Metalloprotease-3 (MMP-3)**: Displays a Kd value of 17,000,000 nM. - **HDAC1**: Inhibits with an IC50 of 625,000 nM. - **Polymerase Kappa**: Highly potent with a potency of 56.2 nM. 2. **Antibacterial and Antiviral Activities**: - **Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, and Escherichia coli**: MIC > 128 µg/mL. - **Helicobacter pylori**: Antibacterial effect with a bacterial eradication rate of 44.4% in in vivo studies. - **SARS-CoV-2**: Exhibits activity against virus-induced cytotoxicity in Vero-6 cells at a concentration of 10 µM. 3. **Other Bioactivities**: - **Human HDAC6**: Shows up to 27.12% inhibition in enzymatic assays. - **Matrix Metalloprotease-13 (MMP-13)**: Displays a binding constant (Kb) of 1,200 nM, indicating competitive inhibition. - **Anthrax Lethal Factor, MMP1, MMP2, MMP3, and MMP8**: Shows varied inhibitory activities. Acetohydroxamic acid also presents potential pharmaceutical applications due to its inhibition of liver enzymes, urease, and carbonic anhydrase, making it a candidate for further research in treating urease-related conditions, bacterial infections, and possibly certain viral infections..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Acetohydroxamic acid (N-Hydroxyacetamide) is an antagonist of the bacterial enzyme urease.
别名	乙酰氧肟酸, oxime, N-Hydroxyacetamide, Methylhydroxamic acid, Lithostat, AHA, Acetic acid

化学信息

分子量	75.07
分子式	C₂H₅NO₂
CAS No.	546-88-3
Smiles	C(NO)(C)=O
密度	1.2269 g/cm3 (Estimated)

储存&溶解度

存储

溶解度信息

DMSO: 60 mg/mL (799.25 mM), Sonication is recommended.

H2O: 199.8 mM, Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (26.64 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	13.3209 mL	66.6045 mL	133.2090 mL	666.0450 mL
5 mM	2.6642 mL	13.3209 mL	26.6418 mL	133.2090 mL
10 mM	1.3321 mL	6.6605 mL	13.3209 mL	66.6045 mL
20 mM	0.6660 mL	3.3302 mL	6.6605 mL	33.3023 mL
50 mM	0.2664 mL	1.3321 mL	2.6642 mL	13.3209 mL
100 mM	0.1332 mL	0.6660 mL	1.3321 mL	6.6605 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

MMP Inhibitor inhibit Bacterial Acetohydroxamic acid

Acetohydroxamic acid

Acetohydroxamic acid