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MSA-2 是可口服的非核苷酸 STING 激动剂,MSA-2 的非共价体系二聚体与 STING 纳摩尔亲和力结合。它在同基因小鼠肿瘤模型中显示抗肿瘤活性,与抗 PD-1 协同作用,可刺激肿瘤分泌干扰素-β,诱导肿瘤消退,具有持久的抗肿瘤免疫。[3]
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MSA-2 是可口服的非核苷酸 STING 激动剂,MSA-2 的非共价体系二聚体与 STING 纳摩尔亲和力结合。它在同基因小鼠肿瘤模型中显示抗肿瘤活性,与抗 PD-1 协同作用,可刺激肿瘤分泌干扰素-β,诱导肿瘤消退,具有持久的抗肿瘤免疫。[3]
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 987 | In stock | |
2 mg | ¥ 1,470 | In stock | |
5 mg | ¥ 2,480 | In stock | |
10 mg | ¥ 3,690 | In stock | |
25 mg | ¥ 5,960 | In stock | |
50 mg | ¥ 8,250 | In stock | |
100 mg | ¥ 10,900 | In stock | |
500 mg | ¥ 22,200 | In stock | |
1 mL x 10 mM (in DMSO) | ¥ 2,590 | In stock |
MSA-2 相关产品
产品描述 | MSA-2 is an orally available non-nucleotide STING agonist. The non-covalent dimer of MSA-2 binds to STING with nanomolar affinity. It shows anti-tumor activity in syngeneic mouse tumor models, synergizes with anti-PD-1, stimulates tumor secretion of interferon-β, induces tumor regression, and has long-lasting anti-tumor immunity. [3] |
靶点活性 | human STING isoforms HAQ:24 μM, human STING isoforms WT:8.3 μM |
体外活性 | 方法:PK-15细胞分别用浓度为20、30、40和50μM的MSA-2处理24小时,然后在10MOI下用SVV感染。感染后24 h(hpi)通过RT-qPCR检测处理细胞中SVV RNA水平。 |
体内活性 | 方法:EMT-6小鼠模型使用MSA-2(50 mg/kg,口服)处理,探讨了体内 MSA-2 处理后肿瘤内细胞因子和趋化因子的改变。 |
动物实验 | Animal Model was MC38 tumor-bearing C57BL6 mice,and The dosage was 60 mg/kg.Administration was P.o.;s.c (50 mg/kg);single dose[1] |
分子量 | 294.32 |
分子式 | C14H14O5S |
CAS No. | 129425-81-6 |
Smiles | COc1cc2cc(sc2cc1OC)C(=O)CCC(O)=O |
密度 | 1.336 g/cm3 (Predicted) |
颜色 | Yellow |
物理性状 | Solid |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 255 mg/mL (866.4 mM), Sonication and heating to 80℃ are recommended. ![]() | |||||||||||||||||||||||||||||||||||
体内实验配方 | 0.5% CMC-Na: 12.5 mg/mL (42.47 mM), Suspension. 请按顺序添加溶剂,在添加下一种溶剂之前,尽可能使溶液澄清。如有必要,可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考,体内配方并不是绝对的,请根据不同情况进行调整。![]() | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。
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