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Ketorolac
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很棒纯度: 99.68%
货号 T21412Cas号 74103-06-3
别名 酮咯酸, Toradol, Sprix, Macril, Acuvail, Acular
Ketorolac (Acuvail) 是非甾体抗炎剂，是非选择性的COX 抑制剂，对 COX-1 和 COX-2 的IC50值分别为 20 和 120 nM。
Ketorolac
一键复制产品信息 很棒纯度: 99.68%
货号 T21412 别名 酮咯酸, Toradol, Sprix, Macril, Acuvail, AcularCas号 74103-06-3
Ketorolac (Acuvail) 是非甾体抗炎剂，是非选择性的COX 抑制剂，对 COX-1 和 COX-2 的IC50值分别为 20 和 120 nM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 mg | ¥ 133 | 现货 | |
| 500 mg | ¥ 278 | 现货 | |
| 1 g | ¥ 392 | 现货 | |
| 2 g | ¥ 579 | 现货 | |
| 5 g | ¥ 963 | 现货 | |
| 10 g | ¥ 1,420 | 待询 | |
| 1 mL x 10 mM (in DMSO) | ¥ 147 | 现货 |
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产品介绍
Ketorolac AI Summary
Ketorolac demonstrates a wide array of bioactivities including significant anti-inflammatory and analgesic effects at various dosages. Specifically, it inhibits carrageenan-induced edema in rats at 15 mg/kg, phenylquinone-induced writhing in mice at 70 mg/kg, cotton pellet granuloma in mice at 0.5 mg/kg, and adjuvant-induced arthritis in rats at 2.0 mg/kg. However, it also induces chronic gastrointestinal erosive activity in rats at 5.0 mg/kg. The therapeutic ratio of gastrointestinal erosion to anti-inflammatory activity in rat paw is 18.0, suggesting a favorable balance.
Pharmacokinetic studies show that Ketorolac has high oral bioavailability (≥80%), rapid absorption with a Tmax of 1 hour, and moderate systemic clearance. It exhibits high plasma protein binding (99.2%) and moderate lipophilicity (LogP ~2.7). Specific enzyme inhibition includes COX-1 with an IC50 of 13.0 nM, COX-2 with an IC50 of 424.0 nM, and prostaglandin synthetase activity in mouse brain microsomes with an IC50 of 230.0 nM. Ketorolac also demonstrates properties such as a moderate pKa of 3.49, acceptable chemical stability, and diverse bioactivities including potential antiviral and antihyperalgesic effects.
Despite its therapeutic potential, Ketorolac shows moderate risk for liver toxicity and gastrointestinal side effects, with an ulcerogenic effect comparable to ketorolac and a notable liver toxicity severity score. Overall, Ketorolac is a potent anti-inflammatory and analgesic agent with a complex pharmacological profile, necessitating careful consideration of its side effects in therapeutic applications..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Ketorolac (Acuvail) is a non-steroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives. It acts by inhibiting the bodily synthesis of prostaglandins. |
| 靶点活性 | COX-1:20 nM, COX-2:120 nM |
| 别名 | 酮咯酸, Toradol, Sprix, Macril, Acuvail, Acular |
| 分子量 | 255.27 |
| 分子式 | C15H13NO3 |
| CAS No. | 74103-06-3 |
| Smiles | OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 |
| 密度 | 1.398 g/cm3 |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 45 mg/mL (176.28 mM), Sonication is recommended.  H2O: 70 mg/mL (274.22 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， 一共给药动物10只，您使用的配方为5%
DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
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